1. The Open PHACTS Ecosystem Fostering a user community Open PHACTS Community Workshop June 2014

2. Open PHACTS Mission: Integrate Multiple Research Biomedical Data Resources Into A Single Open & Free Access Point

3. http://dx.doi.org/10.1016/j.websem.2014.03.003 The Open PHACTS Discovery Platform Cloud-Based “Production” Level System. Secure & Private Guided By Business Questions Uses Semantic Web Technology But provides a simple REST-ful API for the everyone else http://dx.doi.org/10.1016/j.drudis.2013.05.008

4. Getting Started Guide: http://www.slideshare.net/pgroth/ops-developerwebinarjuly312013

5. Drug Disease (1.4) PathwayTarget https://dev.openphacts.org/

6. ComponentsWorkflows

7. Our Response: 1.4 : Batch Mode for *info methods 1.5+ : –Further batch mode queries –Summary methods (“google maps like”)

8. Why Use Open PHACTS? Adding Further Value

9. Directly Working With Data Owners

10. P12047 X31045 P12047 GB:29384 RS_2353

11. ChemSpider Validation & Standardization Platform http://bit.ly/NZF5VB Quality Assurance

14. http://www.openphacts.org/specs/2013/WD-datadesc-20130912/

15. Science-Driven Dynamic Integration http://bit.ly/1gzOhS2 “What are the physiochemical properties of warfarin salts, tautomers or stereo-isomers?” “What are the biological responses to warfarin?”

16. Is Anybody Using It?

17. API Hits (April 2013 – March 2014) 15.8 million total hits

18. An “App Store”? http://www.openphactsfoundation.org/apps.html Explorer Explorer2 ChemBioNavigator Target Dossier Pharmatrek Helium MOE Collector Cytophacts Utopia Garfield SciBite KNIME Mol. Data Sheets PipelinePilot scinav.it Taverna

19. Road Map

20. Version 1.4 API (Coming Soon) –Disease –> Target relationships via DisGeNet –Batch Mode Queries –Performance Improvements

21. Next Step Priorities –Establish the Open PHACTS foundation Recruit members and partners –Further develop resources Open chemical patent data (SureChEMBL) Further Gene-Disease associations (DisGeNet) Enhance pathway data Develop the Open PHACTS VM Faster data update cycle

22. Future Data Sources –Bio-assay Ontology queries –Better handling of biotherapeutics –Adverse Event Data –Disease Ontology queries –Integrate Reactome –Integrate IUPHAR What would you vote for?

23. pmu@openphactsfoundation.orgpmu@openphactsfoundation.org@Open_PHACTS Open PHACTS Practical Semantics Pfizer Limited – Coordinator Universität Wien – Managing entity Technical University of Denmark University of Hamburg, Center for Bioinformatics BioSolveIT GmBH Consorci Mar Parc de Salut de Barcelona Leiden University Medical Centre Royal Society of Chemistry Vrije Universiteit Amsterdam Novartis Merck Serono H. Lundbeck A/S Eli Lilly Netherlands Bioinformatics Centre Swiss Institute of Bioinformatics ConnectedDiscovery EMBL-European Bioinformatics Institute Janssen Esteve Almirall OpenLink Scibite The Open PHACTS Foundation Spanish National Cancer Research Centre University of Manchester Maastricht University Aqnowledge University of Santiago de Compostela Rheinische Friedrich-Wilhelms-Universität Bonn AstraZeneca GlaxoSmithKline