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Seminar assignment Handed out at course start Group work/individual assessment Research based aspects, requires independent work Obtain appropriate information.

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Presentation on theme: "Seminar assignment Handed out at course start Group work/individual assessment Research based aspects, requires independent work Obtain appropriate information."— Presentation transcript:

1 Seminar assignment Handed out at course start Group work/individual assessment Research based aspects, requires independent work Obtain appropriate information - lectures, discussions, web, articles..… Time scheduled to prepare answer Presentation of assignment in seminar format: Groups 3, 4, 5 + 6Friday 19th November Groups 1 + 2Thursday 25th November Grading = pass / fail

2 Seminar assignment Why? Training for the exam Attain “core” knowledge Apply knowledge from previous courses Sort out misunderstandings

3 1. How could lipid accumulation in the liver be due to defects in adipose tissue? Seminar assignment Cusi K. Curr Diab Rep (2010) 10: 306-315

4 Seminar assignment Association between liver fat accumulation and a single nucleotide polymorphism (SNP) located in the promoter of gene X in a putative binding site for peroxisome proliferator activated receptors (PPARs). 2. Describe the molecular mechanism of action of PPARs

5 Seminar assignment 3. Calculate the frequency of each of the alleles

6 Seminar assignment Your task is to design three complementary research studies in order to explore the medical importance of the SNP Study 1. A confirmative human study of your preliminary findings that is population based (~5000 individuals). Study 2. An individually based human study consisting of ~50 individuals that could test whether drugs could influence the degree of hepatosteatosis depending on the SNP in gene X Study 3. Design and describe an in vitro study that will investigate the putative underlying molecular mechanisms using commercially available cell lines

7 Seminar assignment Handed out at course start Group work/individual assessment Research based aspects, requires independent work Obtain appropriate information - lectures, discussions, web, articles..… Time scheduled to prepare answer Presentation of assignment in seminar format: Groups 3, 4, 5 + 6Friday 19th November Groups 1 + 2Thursday 25th November Grading = pass / fail

8 Time in schedule for Groups 3 + 4 to work with seminar assignment

9 Group 3: 9.00-10.30 Addison Group 4: 10.30-12.00 Addison

10 Time in schedule for Groups 5 + 6 to work with seminar assignment

11 Group 5: 9.00-10.30 Einthoven Group 6: 10.30-12.00 Einthoven

12 Time in schedule for Groups 1 + 2 to work with seminar assignment

13 Group 1: 10.00-11.30 Addison Group 2: 10.00-11.30 Einthoven

14 Seminar assignment On demand – support session Wednesday Nov 10, 3 pm Register before Tuesday Nov 9 to: sofia.asp@ki.se and ewa.ehrenborg@ki.se Hand in specific questions What it is that needs to be clarified


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