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Trichostatin A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin 1 by Seungjeong Song, Sang Won Kang,

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Presentation on theme: "Trichostatin A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin 1 by Seungjeong Song, Sang Won Kang,"— Presentation transcript:

1 Trichostatin A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin 1 by Seungjeong Song, Sang Won Kang, and Chulhee Choi Cardiovasc Res Volume ():cvp263 August 13, 2009 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

2 Prior exposure to an HDAC inhibitor potentiates neointima formation in balloon-injured arteries. Seungjeong Song et al. Cardiovasc Res 2009;cvr.cvp263 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

3 Effect of TSA on PDGF-induced growth and migration of VSMCs. (A) VSMCs were incubated in the absence or presence of 0.5 µmol/L TSA for 48 h and then treated with 1 µg/L PDGF for an additional 24 h. Seungjeong Song et al. Cardiovasc Res 2009;cvr.cvp263 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

4 The effect of TSA on antioxidant expression and intracellular ROS levels. Seungjeong Song et al. Cardiovasc Res 2009;cvr.cvp263 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

5 Effect of Trx 1 knockdown on the activation of the NADPH oxidase component. Seungjeong Song et al. Cardiovasc Res 2009;cvr.cvp263 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

6 The effect of Trx 1 and Prx 2 inhibition on VSMC growth and migration. Seungjeong Song et al. Cardiovasc Res 2009;cvr.cvp263 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

7 Effect of Trx1 inhibition on Akt activation. Seungjeong Song et al. Cardiovasc Res 2009;cvr.cvp263 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

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