1. Drill: Draw & name 5 isomers of C 3 H 5 NO

2. Important Amines

3. Amino Acids NH 2 O R C C H OH

4. Glycine NH 2 O H C C H OH

5. Alanine NH 2 O H 3 C C C H OH

6. Phenylalanine H 2 N O -CH 2 -CH-C-OH

7. Phenylalanine is changed to tyrosine by the enzyme phenylalanine oxidase (hydroxylase)

8. Tyrosine H 2 N O -CH 2 -CH-C-OH HO

9. Excess phenylalanine is broken down by amine removal to phenylpyruvic acid

10. Phenylpyruvic Acid O O -CH 2 -C-C-OH

11. Neurotransmitters Transmit chemical signals in the synapse between nerve cells as well as other places

12. Phenol OH

13. Catachol OH

14. Catacholamine H 2 N R OH OH

15. A large number of neurotransmitters are derivatives of catacholamine

16. Phenylalanine H 2 N O -CH 2 -CH-C-OH

17. Tyrosine H 2 N O -CH 2 -CH-C-OH HO

18. l -DOPA H 2 N O -CH 2 -CH-C-OH HO

19. Dopamine -CH 2 -CH 2 -NH 2 HO

20. Norepinephrine OH -CH-CH 2 -NH 2 HO

21. Epinephrine OH CH 3 -CH-CH 2 -N H HO

22. Amphetamine 1-phenyl-2-propylamine CH 3 -CH 2 -CH-NH 2 Upper

23. Methylamphetamine CH 3 CH 3 -CH 2 -CH-NH Upper

24. Seratonin HO N CH 2 -CH 2 -NH 2 H

25. Ephedrine OH CH 3 -CH 2 -CH 2 -NH 2 Decongestant

26. Neosynephrine OH CH 3 -CH-CH 2 -N H Decongestant HO

27. Draw & Name 5 isomers of: C 3 H 7 NO

28. Histamine NN H CH 2 -CH 2 -NH 2

29. Benadryl CH 3 - CH-O-CH 2 -CH 2 -N CH 3 Antihistamine

30. Barbiturates

31. Barbituric Acid O O O N N H H

32. Add Na to get Sodium Barbiturate O O O N: -1 N Na +1 H

33. Barbital O O O N N H H

34. Phenobarbital O O O N N H H

35. Alkaloids

36. Tropane N CH 3

37. Cocaine N CH 3 O O O O

38. Opiates

39. Morphine O HOOH N CH 3

40. Isoprene Terpenes

43. Myrcene 10 carbons

44. Terpenes 5 C - isoprene 10 C – myrceneBO 15 C – farneseneCit 30 C – squalene SLO 40 C – lycopenePP

45. Cyclopentanophenanthrene Steroids

46. Cholestane

47. HO Cholesterol

48. Lab: Today Review: Tuesday Test: Thursday

49. Drill: Draw & Name 5 isomers of: C 3 H 7 NO

50. Test Review

51. Know Common Amines, Amides, & Nitriles

52. Amine production

53. Predict All for Rxns in Base: Isopropyl iodide + ammonia Phenyl bromide + methylamine 1-iodobutane + diethylamine

54. Amide production

55. Predict All For: Acetic acid + ammonia Formic acid + ethylamine Benzoic acid + dimethylamine

56. Nitrile production

57. Predict all for the dehydration of: Benzoamide Propanoamide

58. Hydrolysis Synthesis of: Esters & Amines

59. Hydrolysis of: Amides & Nitriles

60. Predict all for the hydrolysis of: 3-phenylpropanoamide octanoamide

61. Aminolysis Rxns

62. Predict all for the aminolysis of: Phenylformate Aceticbutanoic anhydride

63. Know general neuro- transmitters

64. ORGANIC HW For Monday: Work 1 – 20 on the Final Review