1. Integration architecture Queryable sources that generate XML Distributed queries over sources Query Manager to manage queries Saved queries as sources that can also be queried Leads to potential for query networks

2. vSPARQL Service vSPARQL Service RDF Store RDF Store

3. vSPARQL Service vSPARQL Service RDF Store RDF Store

6. vSPARQL Service vSPARQL Service RDF Store RDF Store

7. QM DB vSPARQL Service vSPARQL Service QM Server QM Client RDF Store RDF Store

10. QM DB vSPARQL Service vSPARQL Service QM Server QM Client RDF Store RDF Store

11. XML BIRN fMRI Study Label using Talairach Demon Extract centers of activation BIRN fMRI Study Schizophrenics vs Healthy Controls

13. XML

14. QM DB vSPARQL Service vSPARQL Service QM Server RDF/ OWL XML QM Client RDF Store RDF Store

15. QM DB vSPARQL Service vSPARQL Service DXQuery Service DXQuery Service QM Server RDF/ OWL XML QM Client RDF Store RDF Store

18. QM DB vSPARQL Service vSPARQL Service DXQuery Service DXQuery Service QM Server RDF/ OWL QM Client RDF Store RDF Store XML

19. QM DB vSPARQL Service vSPARQL Service DXQuery Service DXQuery Service QM Server RDF/ OWL QE Service QE Service QM Client RDF Store RDF Store XML

20. QM DB vSPARQL Service vSPARQL Service DXQuery Service DXQuery Service QM Server RDF/ OWL QE Service QE Service QM Client RDF Store RDF Store XML

27. QM DB vSPARQL Service vSPARQL Service DXQuery Service DXQuery Service QM Server XML RDF/ OWL QE Service QE Service QM Client RDF Store RDF Store XML

30. Region FilteredHealthy (Red) Schizo- phrenic (Yellow) Dorso_lateral prefrontal cortex 552530 Brodmann area 6213107106 Frontal lobe575288287 N=1741

31. QM DB vSPARQL Service vSPARQL Service DXQuery Service DXQuery Service QM Server QE Service QE Service QM Client RDF Store RDF Store

32. QM DB Remote Services Remote Services vSPARQL Service vSPARQL Service DXQuery Service DXQuery Service Other Services Other Services QM Server Other Client XML RDF/ OWL XML QE Service QE Service Other Client QM Client RDF Store RDF Store RDF/ OWL Remote Services Remote Services

33. Remote Services Remote Services vSPARQL Service vSPARQL Service DXQuery Service DXQuery Service Other Services Other Services Other Client XML RDF/ OWL XML Other Client QM Client RDF Store RDF Store RDF/ OWL Remote Services Remote Services Query Manager Core Query Manager Core

34. Remote Services Remote Services vSPARQL Service vSPARQL Service DXQuery Service DXQuery Service Other Services Other Services Other Client XML RDF/ OWL XML Other Client QM Client QM Client RDF Store RDF Store RDF/ OWL Remote Services Remote Services Query Manager Core Query Manager Core Query Manager Core with Plugins

35. Remote Services Remote Services Other Client Remote Services Remote Services Query Manager Query Manager RDF/ OWL XML

36. Query Manager Query Manager RDF/ OWL XML

37. Query Manager Query Manager BIRN fMRI and FMA BIRN fMRI FMA

38. Query Manager Query Manager BIRN fMRI, VBM and FMA BIRN fMRI FMA VBM

39. Query Manager Query Manager Electronic Data Capture and Freezer Management Freezer Management EDC

40. Query Manager Query Manager Biorepositories Biorepository

41. Query Manager Query Manager Human Studies Database Clinical Trials Metadata Ontology of Clinical Research

42. Query Manager Query Manager Ontology Views Ontology

43. Query Manager Query Manager Summary

44. Issues Response time Reliability Security Discoverability Usability Integration with other systems and methods

45. Query Manager Query Manager Query Manager Query Manager Future Work

46. Query Manager Query Manager Query Manager Query Manager Query Manager Query Manager

47. BIRN fMRI FMA Brain Imaging View

48. EDC Clinical View

49. Clinical Imagin g Clinical/I maging View

50. Genomic View Gene Protein Others….

51. Clinical/I maging Genomic Translational View

54. Query Web

55. Translational Medicine

56. Web Semantic Web Internet Query Web A Network-centric view of information systems

57. Bin Zhang

58. A convergence? Biology as an information science Information science as biology Networks as the link

59. Credits Todd Detwiler Onard Mejino Joshua Franklin Ron Shaker Xenia Hertzenberg Nolan Nichols Marianne Shaw Wayne Warren Linda Shapiro Dan Suciu Cornelius Rosse Funding: NLM, NIMH, NHLBI