1. We Treat Alzheimers 20 years early? Can

2. Clinical neurologist-Reisa Sperling 1. Is a clinical neurologist, a neuroimaging researcher. 2.Is a leading force in the movement towards earlier diagnosis and treatment of Alzheimer’s disease.

3. We wait to treat these diseases only after symptoms are evident

4. By the time that the symptoms of Alzheimer’s disease have percolated up to the surface where recognize it as Alzheimer’s disease dementia that process has been going on in the brain for 10 maybe even twenty years and we can’s see what’s underneath the surface.

5. Mild cognitive impairment(MCI): Mild cognitive impairment causes cognitive changes that are serious enough to be noticed by the individuals experiencing them or to other people, but the changes are not severe enough to interfere with daily life or independent function.

6. Dementi a While symptoms of dementia can vary greatly, at least two of the following core mental functions must be significantly impaired to be considered dementia: 1.Memory 2.Communication and language 3.Ability to focus and pay attention 4.Reasoning and judgment 5.Visual perception

7. What’s Amyloid Beta denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. peptidesamino acidsAlzheimer's diseaseamyloid plaques The normal function of Aβ is not well understood.

10. Movie: Still Alice

11. How do we detect AD in the living brain?

12. You can see on the top row is when a typical normal older individual looks like so they don’t have any amyloid where at least not much in the brain that we can detect all about blue is.

13. Why would we want to detect AD more than a decade before dementia? Alzheimer's detected decades before symptoms