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Published byJosephine Rosemary West Modified over 9 years ago
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Can you guess what these are?
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That’s right…they’re Chromosomes! We can arrange chromosomes into homologous pairs in a karyotype to detect abnormalities that may cause genetic disorders.
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Colchicine added to cells Cells broken open Microscope zooms in Picture of chromosomes taken Chromosomes cut up and arranged And how do scientists do this, you may ask…
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Can you pick out the homologous pairs? How did you identify them? Chromosome = “colored body”
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What is happening here?
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Answer: Amniocentesis – the process of removing amniotic fluid from the uterus of a pregnant woman to diagnose any genetic disorders prior to the baby’s birth. Here’s how it works…
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Normal MaleNormal Female Downs SyndromeTurner’s Syndrome Trisomy 13 Klinefelter’s Syndrome Let’s look at some examples of karyotypes and their corresponding health conditions… Williams SyndromeCri du Chat Syndrome Continue
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Back Identify by XY for chromosome pair 23
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Back Identify by XX for chromosome pair 23
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Where is the chromosomal abnormality? Trisomy 21
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Back Downs Syndrome
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Where is the chromosomal abnormality? Monosomy X
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Back Turner’s Syndrome
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Where is the chromosomal abnormality? Trisomy 13
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Back Trisomy 13 aka Patau Syndrome
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Where is the chromosomal abnormality? XXY on chromosome 23
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Back Klinefelter’s Syndrome
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Williams Syndrome is due to a deletion on chromosome 7. This abnormality is too small to identify on most karyotypes, so fluorescent probes must be used.
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Williams Syndrome The missing genes code for a protein that makes blood vessels elastic Results in problems with the cardiovascular system Back
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Can you find the chromosomal difference?
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Cri du Chat Syndrome Detected by a deletion on chromosome 5 Symptoms: –Abnormal larynx development –Problems with respiratory system –High-pitched cry sounds like a cat 80% come from father’s sperm Back
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Want some more practice? Click the link below to do an interactive karyotyping activity: –Predicting with KaryotypesPredicting with Karyotypes
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