1. Increased Toll-Like Receptor Activity in Patients With Metabolic Syndrome Featured Article: Ishwarlal Jialal, M.D., Ph.D., Beverley A. Huet, Ph.D., Harmeet Kaur, Ph.D., Alexander Chien, B.S., Sridevi Devaraj, Ph.D. Diabetes Care Volume 35: 900-904 April, 2012

2. Study Objective Metabolic syndrome (MetS) is a proinflammatory state, but there is a paucity of data on cellular inflammation in MetS Toll-like receptors (TLRs) are classical pattern recognition receptors of the innate immune response Aim of study was to compare monocyte TLR2 and TLR4 between MetS patients and control subjects Jialal I et al. Diabetes Care 2012;35:900-904

3. Study Design Fasting blood obtained for TLR expression and activity Participants with MetS but no CVD or diabetes compared to control participants Jialal I et al. Diabetes Care 2012;35:900-904

8. Conclusions Both TLR2 and TLR4 expression and activity are increased in the monocytes of patients with MetS This could contribute to increased risk for diabetes and CVD with MetS Jialal I et al. Diabetes Care 2012;35:900-904