1. 1 ICON Quarter 3, 2008 Results ended September 30, 2008 Dr. John Climax, Chairman Mr. Peter Gray, CEO Mr. Ciaran Murray, CFO

2. 2 Certain statements contained herein including, without limitation, statements containing the words “believes,” “anticipates,” “intends,” “expects” and words of similar import, constitute forward-looking statements concerning the Company's operations, performance, financial condition and prospects. Because such statements involve known and unknown risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Given these uncertainties, prospective investors are cautioned not to place undue reliance on such forward-looking statements. The Company undertakes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. Forward Looking Statement

3. 3 Quarterly Net Revenue Growth

4. 4 Quarterly Operating Income

5. 5 Quarterly Operating Margins

6. 6 Quarterly Clinical Core Operating Margin

7. 7 Quarterly Central Laboratory Operating Margin

8. 8 Quarterly Earnings per Share and Net Income

9. 9 September 30, 2008 June 30, 2008Dec 31, 2007 Net Cash/(Debt) 55.66.923.8 Net Accounts Receivable 189.4202.4178.0 DSOs54 Days58 Days66 Days Balance Sheet $ million

10. 10  Outlook

11. 11 Business Wins

12. 12 Total Backlog

13. 13 Backlog forecast to be earned in the next 12 months (US$ & % of total forecasts)

14. 14 Questions & Answers Dr John Climax, Chairman Mr Peter Gray, CEO Mr Ciaran Murray, CFO

15. 15 Q3 net revenues ↑ 35.1% Q3 income from operations ↑ 45.1% Q3 operating margin of 12% Q3 EPS ↑ 45.8% $350 million of net new business wins Book-to-bill ratio 1.6 Summary Quarter 3, 2008