3. THE MARBURG-VIRUS

4. animal-borne RNA virus filovirus family causes Marburg haemorrhagic fever (MHF) a form of viral hemorrhagic fever Marburg-Virus (MARV)

5. History First outbreak in Germany 1967 Work with grivet monkeys from uganda to produce vaccines against polio 29 infections – 7 deaths

6. Transmitted from animal host -> human Fruit bats & african green monkeys Afterwards person-to-person contact Transmission

8. YearCountryVirus subtypeCasesDeaths Case fatality rate 2008 Netherland Marburg11100% (ex-Uganda) 2008 USA Marburg100% (ex-Uganda) 2007UgandaMarburg4250% 2005AngolaMarburg37432988% 1998 to 2000DRCMarburg15412883% 1987KenyaMarburg11100% 1980KenyaMarburg2150% 1975South AfricaMarburg3133% 1967YugoslaviaMarburg200% 1967GermanyMarburg29724% Table: Chronology of major Marburg Haemorrhagic Fever outbreaks.

9. Signs & Symptoms Incubation period ~ 5-10 days starts with:fever/chills/headache/myalgia rashes in thoracic/abdominal region nausea/vomiting/abdominal pain/ diarrhea Chest pain/ sore throat Increasingly severe symptops: jaundice/pancreatitis/delirium/massiv hemorrhaging/multi- organ dysfunction

10. Treatment & Vaccines No specific treatment for MHF Sever cases require supportive care Vaccines are currently tested with success but not available yet

11. Sources http://www.enivd.de/FS/fs_encdiseases.htm http://www.cdc.gov/vhf/marburg/index.html http://www.who.int/mediacentre/factsheets/fs_marburg/ en/ http://www.who.int/mediacentre/factsheets/fs_marburg/ en/ https://de.wikipedia.org/wiki/Marburg-Virus#Geschichte http://www.faz.net/aktuell/wissen/medizin/seuche-in- marburg-eine-stadt-sucht-einen-moerder-13127002.html http://www.faz.net/aktuell/wissen/medizin/seuche-in- marburg-eine-stadt-sucht-einen-moerder-13127002.html http://www.onmeda.de/krankheiten/marburg_virus_infek tion.html