1. STA 216 Generalized Linear Models Instructor: David Dunson dunson1@niehs.nih.gov 211 Old Chem, 541-3033 (NIEHS)

2. STA 216 Syllabus Topics to be covered:  Definition of GLM: Components, assumptions and motivating examples  The Basics: Exponential family, model fitting, and analysis of deviance  Binary Data (Models): Link functions, parameter interpretation, & prior specification  Binary Data (Computation): Approximations and MCMC algorithms

3. Topics (Page 2)  Binary Data (Probit Models): Underlying normal structure and Albert & Chib Gibbs sampler  Ordered Categorical Data: Probit models, common link functions, and examples  Unordered Categorical Data: Multinomial choice models, common link functions and examples  Log-Linear Models: Poisson distribution, parameter interpretation, over-dispersion and examples

4. Topics (Page 3)  Discrete-Time Survival Models: Relationship with binary data models, convenient forms & examples  Continuous-Time Survival: Proportional hazards model, counting processes & implementation  Accounting for Dependency: Mixed models for longitudinal and multilevel data  Multivariate GLMs: Generalized linear mixed models for multivariate response data

5. Topics (Page 4)  Models for Mixed Discrete & Continuous Outcomes: Underlying normal & GLMM approaches  Advanced Topics: Incorporating parameter constraints Hidden Markov and multi-state modeling Case Studies: Fertility and tumorigenicity applications Non- and semi-parametric methods Identifiability & improved methods for computation

6. Student Responsibilities:  Assignments: Outside reading and problems sets will typically be assigned after each class (10%)  Mid-term Examination: An in-class closed-book mid term examination will be given (30%)  Project: Students will be expected to write-up and present results from a data analysis project (30%)  Final Examination: The final examination will have both in-class (15%) & out of class problems (15%)