1. Cell Membrane Part 2

2. 2 Carrier Proteins Other carrier proteins change shape to move materials across the cell membrane Other carrier proteins change shape to move materials across the cell membrane

3. 3 Active Transport  Requires energy or ATP  Moves materials from LOW to HIGH concentration  AGAINST concentration gradient

4. 4 Active transport  Examples: Pumping Na + (sodium ions) out and K + (potassium ions) in against strong concentration gradients.  Called Na+-K+ Pump

5. 5 Sodium-Potassium Pump 3 Na+ pumped in for every 2 K+ pumped out; creates a membrane potential

6. 6 Moving the “Big Stuff” Molecules are moved out of the cell by vesicles that fuse with the plasma membrane. Exocytosis Exocytosis- moving things out. This is how many hormones are secreted and how nerve cells communicate with one another This is how many hormones are secreted and how nerve cells communicate with one another.

7. 7 Exocytosis Exocytic vesicle immediately after fusion with plasma membrane.

8. 8 Moving the “Big Stuff” Large molecules move materials into the cell by one of three forms of endocytosis Large molecules move materials into the cell by one of three forms of endocytosis.

9. 9Pinocytosis Most common form of endocytosis Most common form of endocytosis. Takes in dissolved molecules as a vesicle Takes in dissolved molecules as a vesicle.

10. 10 Pinocytosis Cell forms an invagination Cell forms an invagination Materials dissolve in water to be brought into cell Materials dissolve in water to be brought into cell Called “Cell Drinking” Called “Cell Drinking”

11. 11 Example of Pinocytosis pinocytic vesicles forming mature transport vesicle Transport across a capillary cell (blue).

12. 12 Receptor-Mediated Endocytosis Some integral proteins have receptors on their surface to recognize & take in hormones, cholesterol, etc.

13. 13 Receptor-Mediated Endocytosis

14. 14 Endocytosis – Phagocytosis Used to engulf large particles such as food, bacteria, etc. into vesicles Called “Cell Eating”

15. 15 Phagocytosis About to Occur

16. 16 Phagocytosis Phagocytosis - Capture of a Yeast Cell (yellow) by Membrane Extensions of an Immune System Cell (blue)

17. 17 Exocytosis The opposite of endocytosis is exocytosis. Large molecules that are manufactured in the cell are released through the cell membrane. Inside Cell Cell environment