1. 1

2. Age Diabetes mellitus, HTN, hypeuricemia 2

3. Factors with protective influence on OA Reproductive variables (Estrogens) Osteoporosis Smoking 3

4. 4

5. 5

6. 6

7. 7

8. 8

9. 9

10. Pain on effort 10

11. 11

12. 12

13. 13

14. 14

15. 15

16. 16

17. 17

18. 18

19. 19

20. 20

21. 21

22. 22

23. 23

24. 24

25. 25

26. 26

27. 27

28. Therapy used for patients with OA Education Exercise therapy Hydrotherapy Footwear and walking aids Systemic drug therapy Intra-articular drug therapy Rubefaciens and other local applications Surgery: arthroscopy, osteotomy, joint replacement, arthrodesis Complimentary techniques for pain relief: chiropractic, acupuncture, shiatsu, massage, herbal 28

29. Exercise Joint replacement NSAIDs IA steroids DietSYSADOA IA hyaluronate opioidsVitamines Sex hormones Minerals Psychotropic drugs Sticks Insoles Exercise Joint replacement NSAIDs IA steroids Diet SYSADOA IA hyaluronate Osteotomy Arthroscopy Spa Telephone Vitamines Sex hormones Minerals Psychotropic drugs Sticks Insoles 29

30. 30