1. CATIE STUDY Clinical Antipsychotic Trials of Intervention Effectiveness Effectiveness of Antipsychotic Drugs in patients with Chronic Schizophrenia – Lieberman J et al (2005) NEJM

2. CATIE 1493 Participants 57 US sites 5 arms Olanzapine (7.5 to 30mg daily) Perphenazine (8 to 32 mg daily) Quetiapine (200 to 800mg daily) Risperidone (1.5 to 6.0 mg daily) Ziprasidone (later) 40 to 160mg a day

3. CATIE 3 Phases Initial randomisation (Phase 1) Then re-randomised if no response Paper here reports Phase 1 18 months 2001-4

4. CATIE 18-65 DSM schizophrenia (chronic) SCID –IV Exclusions schizoaffective, learning disability, only one schizophrenic episode, treatment resistance, sensitivity known to any of drug arms, “cognitive disorder”, clozapine, pregnant or breast feeding, serious or unstable medical disorder

5. CATIE Tablets of identical appearance for blinding Dosage flexible 1-4 tablets Concomitatnt medication permitted exceot antipsychotics Monthly visits Half patients on other drugs assigned to once daily and half to twice daily for drugs with od regime as quetiapine and ziprasidone bd and could unblind

6. CATIE ITT Kaplan Meier Cox proportional-hazards MANOVA/MANCOVA