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This is what would happen under the myelin sheath. At the end of the myelin sheath, the membrane potential would still be above.

Published byMyra Long Modified over 9 years ago

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Presentation on theme: "This is what would happen under the myelin sheath. At the end of the myelin sheath, the membrane potential would still be above."— Presentation transcript:

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13 This is what would happen under the myelin sheath. At the end of the myelin sheath, the membrane potential would still be above threshold, and the action potential would be regenerated.

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25 1994 Nobel Prize in Medicine Alfred G. GilmanMartin Rodbell

26 http://nobelprize.org/medicine/laureates/1994/illpres/index.html (1) Resting state (2) Receptor activates G protein (3) Alpha sub-unit separates and has action on amplifier (4) Alpha sub-unit breaks off of amplifier and recombines with other sub-units

27 A first messenger (1) binds to a specific receptor (2) The transducer (3), a G protein – composed of alpha-, beta- and gamma subunits – is activated This stimulates the amplifier (4), adenylate cyclase, which produces (5) the second messenger, cyclic AMP, from (6) ATP (adenosine triphosphate) (7) A cascade of enzymatic reactions alters the behavior of the cell and (8) via phosphorylation, an ion channel (11) is opened. Note: ignore (9) and (10) A specific example of how a G-protein activates cAMP

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