1. I ELECTRON TRANSPORT CHAIN (ETC) Dr. Samah Kotb Lecturer of Biochemistry 2015 Cellular Biochemistry and metabolism 2 CLS 333

2. Electron Transport Chain (ETC) C HAPTER 7

3. ELECTRON TRANSPORT CHAIN (ETC) The electron transport chain is a series of protein complexes embedded in the mitochondrial membrane.

4. ELECTRON TRANSPORT CHAIN (ETC) In the TCA cycle 3 molecules of NADH and one of FADH2 are Produced. The Hydrogen atoms on these reduced coenzymes are removed and split into protons + electrons. The protons dissolve and disappear in the aqueous medium of the mitochondrial matrix. The electrons are transported along a chain of protein type molecules attached in a specific sequence to the inner mitochondrial membrane. At the end of the chain the electrons are received by oxygen which gets reduced to water.

5.  At the electrons move from one membrane of the chain to the next, they lose energy. This energy is used by the cell to synthesize ATP from ADP and Pi.  There are 7 member molecules of the chain.  Electrons coming from NADH travel enough distance and loose enough energy to allow the cell to synthesize 3 ATP molecules. However electrons coming from FADH 2 will lose enough energy to allow the cell to synthesize only 2 ATP molecules. ELECTRON TRANSPORT CHAIN (ETC)

9.  The electrons carried on NADH after adding energy will synthesis 3 ATP.  The electrons carried on FADH 2 after adding energy will synthesis 2 ATP.

10. Number of ATP molecules synthesized as a result of complete degradation of one glucose molecule Number of ATP molecules synthesized as a result of complete degradation of one glucose molecule 1) Glycolysis: ELECTRON TRANSPORT CHAIN (ETC)

11. Number of ATP molecules synthesized as a result of complete degradation of one glucose molecule 2. Pyruvate Oxidation

12. 3. TCA cycle Number of ATP molecules synthesized as a result of complete degradation of one glucose molecule

13. Total Net: Glycolysis = 2 ATP Reaction 6 (ETC) = 6 ATP Pyruvate Oxidation (ETC) = 6 ATP 2 turns of TCA cycle = 24 ATP  TOTAL = 38 ATP

16. Thank you 16