1. Electron Transport Chain

2. NADH and FADH 2 are __________________ These electrons are transferred to a series of components that are found in the inner mitochondrial membrane This is known as the _________________________________ Introduction

4. Electron CarrierGlycolysisPyruvate Oxidation Kreb’s Cycle G3PGlucosePyruvateGlucosePyruvateGlucose NADH FADH 2 Therefore, before we enter the electron transport chain we have: ___________

5. The ETC is a series of proteins arranged as a chain on the _______of the inner mitochondrial membrane The components of the ETC are arranged in order of increasing electronegativity: starts with the _______ attractor of electrons and ends with the _________

6. Complexes in the ETC NADH dehydrogenase Ubiquinone (Co-enzyme Q) Cytochrome b-c Cytochrome c Cytochrome oxidase

7. NADH passes its electrons on to Complex I – NADH dehydrogenase FADH 2 passes its electrons to Q (shuttle)

8. Proton Pumps Move protons (H + ions) from the ______________into the _________________________ Protons moving ______________(need energy to do this), the __________moving through the complexes provide this energy A proton gradient is created and the energy powers the ATP synthase enzyme- an ATP pump called an __________ 3 proton pumps ___________

9. NADH passes its electrons on to Complex I – NADH dehydrogenase FADH 2 passes its electrons to Q (shuttle) How many protons get pumped for every NADH? _______ How many protons get pumped for every FADH 2 ? _______

10. Final Electron Acceptor Why do we need oxygen for cellular respiration? ____________________________________________ It takes the _____________from the final proton complex (III) (cyctochrome oxidase) and takes _____________from the matrix and forms _______________ 2e - + 2H + + O 2  H 2 O

11. Chemiosmosis Protons accumulate in the intermembrane space of the mitochondria  this creates an electrochemical gradient ____________________________________________ H + (proton)

12. ATP Synthase The protons cannot move through the phospholipid bilayer ____________________________________________ ____________________________________________ Protons move through the ATPase complex and as a result the synthesis of ATP from ADP and P occur in the matrix

13. How many ATP are formed? Start off with 10 NADH: __________________________ Start off with 2 FADH 2 ___________________________ ____________________________

14. Putting it all together… The Electron Transport Chain: 1. 2. _ _________________________ 3. 4._____________________________