1. PAPILOMAVIRUS

2. Family: PAPOVAVIRIDAE genus: PAPILLOMAVIRUS Genom: ds DNA,

5. (HPV typs 1-4, 7, 10, 26-28)

6. 2. Epidermodysplasia verruciformis (HPV types 5, 8, 9, 12, 14, 15, 17, 19-25) malignat HPV

7. Ca cervix uteri, Ca vulvy, Ca penis (Ca – carcinoma) - 65 % HPV 16 and 18 - 18 % HPV 31, 33, 35, 45, 52, 58 High risk genotypes - High risk genotypes - Probably high risk genotypes - Probably high risk genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 58, 59 26, 53, 66, 68, 73, 82 - Low risk genotypes - Low risk genotypes HPV 6, 11, 40, 42, 43, 44, 54, 61, 70, 72, 81 Munoz et al., Vaccine, 2006

8. Risk factors  Smoking  Contraceptives  HIV

9. 500 000 cases Ca cervix uteri/year

10. Imunocytochemistry Imunocytochemistry capsid Ag capsid Ag Detection DNA Detection DNA Dg. Papanicolaou

11. Gardasil (Merck) (vakcine – HPV 6, 11, 16, 18) Merck Cervarix (GlaxoSmithKline) (vakcine - HPV 16, 18) GlaxoSmithKline Prevention