1. Liver Excision-Cauterization Amine Hallab Kevin Mihelc, Jen Bacior, Hiroki Meguro Kelly Dympna MD, John Patzer PhD University of Pittsburgh Senior Design-BioE 1161 Tuesday January 18th, 2005

2. Outline Background and Overview Design Proposal Responsibilities Achievements Future Work

3. Background and Overview 1 in 10 Americans are or have been afflicted with liver disease Treatments – Liver transplant Liver diseases are poorly understood Liver biopsy – common procedure for afflicted liver diagnosis – Essential tool for metabolic processes research –American Liver Foundation 2003 –Maddrey, W C, “Atlas of the Liver,” 2004, Current Medicine Inc

4. How do surgeons take a liver biopsy ? - Fully excised pig liver - Picture taken by Amine Hallab - BioScience Tower

5. Design Proposal Liver Excision-Cauterization (LEC) LEC Functions – To excise – To cauterize – To provide temperature control »Thermal and electrical insulation » Thermal and electrical conduction t t L α

6. Personal Responsibilities External relations and scheduling Design history file revision Mathematical model – Heat Transfer Structural design and materials – Material selection – Material structural analysis Animal testing

7. Personal Achievements Good foundation on liver biopsy Met with mentors on monthly basis Design History File – PDS, Object Tree Analysis, Function-Means Estimated heat model for structure and materials – Stainless steal and Ceramic – Thickness of materials Testing » Certified for animal testing » Provided a place for testing

8. Future Work January – Heat model for structural design purposes – Prototyping prerequisites February – Prototype process – More calculation – DHF revision March – Compute the math model for various parameters – DHF revision April – Final grant proposal – Animal testing – Final Presentation

9. Acknowledgments Mark Gartner, PhD Department of BioEngineering LEC Group – Hiroki Meguro – Kevin Mihelc – Jen Bacior John Patzer, PhD Kelly Dympna, MD Stephan Safta and Richard Miller