1. Table 3.1.1: Stock and Flow of Heart Transplantation, 1997-2005 Year199719981999200020012002200320042005 New transplant patients 132340201 Deaths 010313100 Retransplanted 000000000 Lost to follow up 000000000 Alive at 31 st December 135585667 N.B. There was no heart transplants carried out in 2004

2. Figure 3.1.1: Stock and Flow of Heart Transplantation, 1997-2005 Number of patients Year 0 1 2 3 4 5 6 7 8 New transplant patients Alive at 31st December 1997 1998 1999 2000 2001 2002 2003 2004 2005

3. Table 3.2.1: Gender distribution, 1997-2005 Year199719981999200020012002200320042005TOTAL GenderNo. Male 13022020111 Female 0021200005 TOTAL 13234020116 Table 3.2.2: Ethnic group distribution, 1997-2005 Year199719981999200020012002200320042005TOTAL Ethnic groupNo. Malay 0011200015 Chinese 0001001002 Indian 1311201009 TOTAL 13234020116

4. Table 3.2.3: Age distribution, 1997-2005 Year199719981999200020012002200320042005TOTAL Age, yearsNo. 0-19 0021100015 20-39 0200000002 40-59 1102302009 >=60 0000000000 TOTAL 13234020116 Mean 5140163738-46-1536 SD -912217-8--16 Median 5137164443-46-1540 Minimum 5133151314-40-1513 Maximum 5150165554-52-1555 Age=date of transplant-date of birth

5. Table 3.2.4: Primary diagnosis, 1997-2005 Year199719981999200020012002200320042005TOTAL Primary diagnosisNo. Ischaemic Cardiomyopathy1301102008 Idiopathic Dilated Cardiomyopathy0021200016 Restrictive Cardiomyopathy0000000000 End Stage Valvular Heart Disease0000100001 Hypertrophic Cardiomyopathy0001000001 Others0000000000 TOTAL13234020116

6. Table 3.3.1: Heart Procedure, 1997-2005 Year199719981999200020012002200320042005TOTAL Heart ProcedureNo. Orthotopic Bicaval1100000002 Orthotopic Traditional02234020114 Heterotopic0000000000 TOTAL13234020116 Table 3.3.2: Immunosuppressive used, 1997-2005 Year 199719981999200020012002200320042005Total Type of immunosuppressiveNo. Steroids Prednisolone13234010115 Methylprednisolone13234020116 Calcineurin Inhibitors Neoral ® 13234010115 Antimetabolites Azathioprine (AZA)13234020015 Mycophenolate Mofetil0000101013 TOTAL patients at notification13234020116

7. Table 3.3.3: Immunosuppressive used at time of last follow-up up to 2005 Year of transplant*199719981999200020012002200320042005TOTAL Type of immunosuppressive No. Steroids Prednisolone1410300009 Methylprednisolone1100100003 Calcineurin Inhibitors Neoral ® 14314020015 Antimetabolites Azathioprine (AZA)1211300008 Mycophenolate Mofetil (MMF)0220102007 TOTAL patients at follow-up12213010010 *Data according to year of transplant of patient

8. Table 3.3.4: Duration of waiting time on waiting list, 1997-2005 Year199719981999200020012002200320042005TOTAL Duration (months)No. <50210101005 5-<101010100014 10-<150001000001 15-<200001000001 20-<250000000000 25-<300000000000 30-<350000000000 35-<400000001001 TOTAL12222020112 Mean 624155-20-99 SD -0165-25--10 Median 624155-20-96 Minimum 623101-2-91 Maximum 625198-37-9 *Duration=date of transplant-date added to wait list

9. Table 3.4.1: Post Transplant Events at last follow-up up to 2005 Year of transplant*199719981999200020012002200320042005TOTAL Type of post transplant eventsNo. Drug Treated Hypertension 12213010010 Bone Disease (Symptomatic) 1000100002 Chronic Liver Disease 0000000000 Cataracts 0000000000 Diabetes 1200001004 Renal Dysfunction 1000100002 Stroke 0000000000 Drug Treated Hyperlipidaemia 12213010010 TOTAL patients at follow-up 12213010010 *Data according to year of transplant of patient

10. Table 3.4.2: Post Transplant Malignancies at follow-up up to 2005 Year of transplant*19971998199920002001200 2 200 3 200 4 200 5 TOTAL Type of post transplant malignanciesNo. Recurrence of pre-transplant tumor 0000000000 De Novo solid tumor 1000000001 De Novo lymphoproliferative disorder 0000000000 Skin 0000000000 TOTAL patients at follow-up 12213010010 *Data according to year of transplant of patient

11. Table 3.4.3: Non-compliance at follow-up up to 2005 Year of transplant*199719981999200020012002200320042005TOTAL Non-compliance during follow-up No.  Yes 0020001003  No 1201300007 TOTAL patients at follow-up 1221301 0 010 Areas of non-compliance:  Immunosuppression medication 0010001002  Patient unable to afford immunosuppression medications 0000000000  Other medication 0000000000  Other therapeutic regimen 0010000001 TOTAL patients with noncompliance 0020001003 *Data according to year of transplant of patient

12. Table 3.4.4: Patient treated for rejection at follow-up up to 2005 Year of transplant*199719981999200020012002200320042005TOTAL Patient treated for rejection No.  Yes 0110000002  No 1111201007 TOTAL patients with follow-up 1221301 0 010 Number of rejection events 11 0100000001 22 0000000000 33 0010000001 TOTAL patients with rejection0110000002 *Data according to year of transplant of patient

13. Table 3.4.5: Time of deaths, 1997-2005 Year of discharge199719981999200020012002200320042005TOTAL Time of deathsNo. <3 months (at discharge) 0102011005 3-<6 months 0000000000 6 months-1 year 0000010001 > 1 year 0001110003 TOTAL patients who died 0103131009 *Time=Date of death–date of transplant

14. Table 3.4.6: Patient survival, year of transplant 1997-2005 Year of Transplant1997-2005 Interval% SurvivalSE 6 months671 1 year601 2 year471 3 year401 SE = standard error *Duration = date follow up-date transplant, if alive at discharge = date of discharge-date of transplant, if dead at discharge

15. Figure 3.4.6: Patient survival, year of transplant 1997-2005 0.00 0.25 0.50 0.75 1.00 Cumulative survival 012345678 Duration in years

16. Table 3.4.7: Cause of death at discharge, 1997-2005 Year199719981999200020012002200320042005TOTAL Cause of deathNo. Hyperacute rejection0000001001 Multi organ failure0001000001 Respiratory failure secondary to septicaemia 0000010001 Respiratory failure, renal function and liver failure, ARDS, septicaemia 0001000001 Septicaemia, multiorgan failure0100000001 TOTAL patients who died at discharge 0102011005

17. Table 3.4.8: Cause of death at follow-up, 1997-2005 Year199719981999200020012002200320042005TOTAL Cause of deathNo. Severe bleeding00000 1 000 1 Lung cancer, small cell type, septicaemia, bronchopneumonia 000 100 000 1 Rejection due to non-compliance00 0 010 000 1 Unknown000 001 000 1 TOTAL patients who died at follow-up 0001120 00 4