1. Calibration WG Overall goals: 2.Develop and implement means for reducing intersite variations in fMRI sensitivity - Procedures on web site - Paper in press: Friedman & Glover, JMRI 1. Develop and maintain scanner QA methods

2. Calibration WG Proposed intersite calibration aims: 1. Further develop BH methods (GHG) 2.Develop ASL methods (Tom Liu) 3. Examine smoothing equalization (Friedman et al., in review) 4. Develop new method based on SFNR (Lee Friedman) Bonus Aim

3. Update on BH Theory and measurements developed Paper on BH kids/adults (Thomason, NI 2005) Paper on BH calib (Thomason, HBM in press) Next steps

4. Children Working Memory Adults Spatial Verbal M. Thomason low high medium low high medium

5. BH-induced BOLD signal Vascular res.   HR    CBF  hypoxia Basal metab.  O 2 , CO 2, NO, H +   vasodilation   rCBF Thomason, et. al, NI 2005

6. Vascular BOLD Uniformity Thomason, et. al, NI 2005

7. BH Task: Children vs. Adults Thomason, et. al, NI 2005

8. BH Task: Children vs. Adults Thomason, et. al, NI 2005

9. BOLD Signal Davis, PNAS (1998) Buxton, 2003 rCBF [HbO2] OEF [Hb] CMRO2 = OEF x rCBF x [HbO2] M. Thomason et al., HBM 2006

10. BOLD Signal Kastrup (1999) Hoge (1999) BH task F = f BH /f a M. Thomason et al., HBM 2006

11. Use BH task (non-neuronal, no change in CMRO2) to normalize cognitive task Reduces signal change related to vasoreactivity Should reduce inter-subject variance BH Calibration Method

12. Adult subjects performed - SWM task (Sternberg) - BH task Compared intersubject variability in WM effect with/without BH calibration WM/BH Study M. Thomason et al., HBM 2006

13. Raw Calib Calibration: WM M. Thomason et al., HBM 2006

14. Calibration: WM Raw pixel- wise ROI whole brain 1 Slice for all subjects M. Thomason et al., HBM 2006

15. Calibration: WM Raw pixel- wise 1 Slice for 3 subjects M. Thomason et al., HBM 2006

16. No calib BH Calibration: Individual Subs Calib 5 ≤ t ≤ 20 M. Thomason et al., HBM 2006

17. Calibration: SWM 5 subjects, parietal M. Thomason et al., HBM 2006

18. No calCalib 3.5 ≤ t ≤ 10 vol = 1.24 @ p.001vol = 1.0 BH Calibration: Group Activation M. Thomason et al., HBM 2006

19. Activation Response M. Thomason et al., HBM 2006 t-score average = 7.82t-score average = 14.58 No calCalib

20. Update on BH Theory and measurements developed Paper published on BH kids/adults Paper in press BH calib Next steps

21. Update on BH Theory and measurements developed Paper published on BH kids/adults Paper in press BH calib Next steps

22. Variations in inspiration may modulate blood oxygenation Vascular Responsivity: BH Sl 10, aud

23. Behavioral Effect Mitigation Approaches Model breathing variations using GLM Signal = a * Resp + b * HR

24. Vascular Responsivity: BH GHG111603

25. Behavioral Effect Mitigation Approaches Model breathing variations using GLM Signal = a * Resp + b * HR Provide respiration feedback to maintain inspiration level constant

26. BH Status Program available to make calibrated timeseries- input = timeseries, BH scan, params Developing feedback device piezo electric resp monitor from ADI LED meter, analog electronics. Est. cost $500