1. Biophysical Immunology Laboratory Thomas Vorup-Jensen Institute for Medical Microbiology and Immunology University of Aarhus Denmark vorup-jensen@microbiology.au.dk

2. Innate Immunity Janeway’s Immunobiology Chapter 2&3 Lecture I:(mainly) Cellular factors Important messanges: Important cell types supporting innate immunity effector functions Important molecular mechanisms in leukocyte functions Molecules of microbial origin triggering an innate immune response 2

3. Humoral Immune response Chap. 10 Antigen capture Chap. 4-6 Cell mediated immunity Chap. 8&9 Immune pathogenesis (autoimmunity & cancer) Several chap. INNATE IMMUNITY Innate immunity: a role everywhere in the immune system 3

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7. (macrophages are diffrentiated monocytes) 7

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10. Further differentiation to macrophage, DC 10

11. (e.g. defensins, lysozyme) 11

12. Time (adaptive immunity) 12

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17. Innate Immunity Janeway’s Immunobiology Chapter 2&3 Lecture I:(mainly) Cellular factors Important message !: Innate immunity protects the body against infection in the early phases of infection Damage to the host may occur as a consequence of innate immunity effector functions – inflammation may be excessive 17

18. How to trigger the complement system: Discrimination between self and non-self by pattern recognition Janeway (1989) Cold Spring Harb Symp Quant Biol 54:1-13 18

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21. Mogensen (2010) Clin. Rev. Microbiol. 22: 240-273

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25. Innate Immunity Janeway’s Immunobiology Chapter 2&3 Lecture I:(mainly) Cellular factors Important message !: Many molecules in innate immunity recognize ”patterns” on microbial surfaces. This recognition leads to triggering on the immune response. 25

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30. Innate Immunity Janeway’s Immunobiology Chapter 2&3 Lecture I:(mainly) Cellular factors Important message !: Innate immunity triggers the production bactericidal compounds and cytokines that control cell migration 30

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38. Downloaded from: StudentConsult (on 29 October 2007 04:52 PM) © 2005 Elsevier 38

39. Carman (2009), J Leuk Biol 122:3025-35 39

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42. Innate Immunity Janeway’s Immunobiology Chapter 2&3 Lecture I:(mainly) Cellular factors Important message !: Adhesion molecules play an important role in supporting contact between leukocytes and inflammed tissue during migration and phagocytosis. 42

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44. Viruses: typically a job for the aqcuired immune system 44

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52. Innate Immunity Janeway’s Immunobiology Chapter 2&3 Lecture II:(mainly) Soluble (humoral) factors Important messages: Important soluble molecules supporting innate immunity effector functions Connection between molecular structure and function in the immune system …to be continued 52