1. Regulatory approval times between submission and marketing authorization approval 2001-2005 APRIL 2007 SOURCE: CMR INTERNATIONAL PERFORMANCE METRICS PROGRAM © THOMSON REUTERS Your use of these materials is subject to the terms and conditions hereof. Please read the disclaimer carefully before using these materials.

2. Regulatory approval times between submission and marketing authorization approval 2001-2005 Box: 25 th and 75 th percentiles Whiskers: 5 th and 95 th percentiles =median (n) = number of active substances receiving marketing authorisation US FDAJapanese PMDA EU Centralised Procedure Median regulatory approval time (years) Year of approval SOURCE: CMR INTERNATIONAL PERFORMANCE METRICS PROGRAM © THOMSON REUTERS

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