1. Basic Translational Clinical New Pathways to Discovery Harmonization Target ID & Valid. Phases I-III Research Teams of Future Translational Cores Clinical Networks Molecular Libraries Clinical and Translational Science Awards { R & D NIH Roadmap: A Systems Approach Across the Research Spectrum Practice Screening/ Optimization Preclinical Fundamental Public-Private Partnerships PPP-Across the entire spectrum

2. NIH Roadmap Molecular Libraries Program: Assay Development for High Throughput Screening http://nihroadmap.nih.gov/molecularlibraries/ Mark Scheideler, Ph.D., Program Director scheidelerm@ninds.nih.gov Fong Wang, Ph.D., Scientific Analyst wangf@ninds.nih.gov

3. Aims of the Program: Extract assays from ongoing research programs, and provide the resourcing needed to configure them for use in probe development projects. Encourage the development of novel assays and assay technologies.

4. Compound Repository Screening Centers Network Molecular Libraries Screening Center Network (MLSCN ) HTS Assays

5. Overall Capabilities of the Screening Center Network GPCRs Enzymes Proteases Protein-Protein interactions High Content Screening High-throughput Microscopy NMR-based methods Protein Translocation Complementary HTS Flow Cytometry Protein Kinases Ion channels Transporters Kalypsys BSL-3