1. Ischemic Heart Disease CVS3 Hisham Alkhalidi

2. Ischemic Heart Disease A group of related syndromes resulting from myocardial ischemia

3. Ischemic Heart Disease The vast majority of ischemic heart disease is due to coronary artery atherosclerosis Less frequent contributions of: – vasospasm – vasculitis Is it exactly the same as coronary artery disease (CAD)? – Frequently yes

5. Angina pectoris Chest pain: – Can radiate down the left arm or to the left jaw (referred pain) – Due to inadequate perfusion – Duration and severity is not sufficient for infarction

6. Stable angina – Occurring reliably after certain levels of exertion – Typically due to atherosclerotic disease with ≥75% (critical stenosis) fixed chronic stable stenosis

7. Unstable angina Unstable (occurring with progressively less exertion or even at rest) Results from a small fissure or rupture of atherosclerotic plaque triggering: Platelet aggregation Vasoconstriction Formation of a mural thrombus that may not be occlusive Usually proceed MI

8. Variant angina Vessel spasm or Prinzmetal angina Without fixed atherosclerotic disease The etiology is not clear

9. Myocardial infarction The severity or duration of ischemia is enough to cause cardiac muscle death Typically results from acute thromboses that follow plaque disruption

11. MI types Transmural – Full thickness (>50% of the wall) Subendocardial – Inner 1/3 of myocardium – Two mechanisms: Fixed atherosclerosis but with increased demand, vasospasm or hypotension OR Evolving transmural with relieve of the obstruction (often multifocal)

12. MI, common locations – In Right dominent coronary artery heart (90% of population): 2 cm proximal LAD (up to 50%) – anterior left ventricle – anterior septum – apex circumferentially Left circumflex ( up to 20%) – infarct involves lateral left ventricle except the apex. 1 st and last thirds of RCA (up to 40%) – posterior left ventricle – posterior septum – right ventricular free wall, sometime

14. Ischemia to myocardium rapidly (minutes) leads to loss of function and causes necrosis after 20 to 40 minutes

16. Clinical picture of MI Severe, crushing substernal chest pain or discomfort that can radiate to the neck, jaw, epigastrium, or left arm Diaphoresis Nausea Dyspnea Can be silent (DM, old age)

17. ECG Changes such as: – Q waves (indicating transmural infarcts) – ST-segment abnormalities – T-wave inversion Arrhythmias

18. Laboratory evaluation Cardiac troponins T and I (TnT, TnI) Creatine kinase (CK, and more specifically the myocardial-specific isoform, CK-MB) Lactate dehydrogenase Myoglobin Troponins and CK-MB have high specificity and sensitivity for myocardial damage

19. Laboratory evaluation TnI and TnT are not normally detectable in the circulation After acute MI both troponins: – Become detectable after 2 to 4 hours – Peak at 48 hours – Their levels remain elevated for 7 to 10 days

20. CK-MB is the second best marker CK-MB activity: – Begins to rise within 2 to 4 hours of MI – Peaks at 24 to 48 hours – Returns to normal within approximately 72 hours

21. Complications of MI At least 80% will suffer: – Cardiogenic shock (>40% infarct of LV) – Congestive heart failureCHF – Arrhythmia – Rupture of ventricle, free wall, septum, or papillary muscle – Aneurysm formation, – Mural thrombus, potentially soursce of emboli – Pericarditis

22. MI death and complications rates 25% die, presumably due to arrythmia 10% of the rest will die within a month 80-90% will develop complications Overall 30% die in the 1 st year and then 10% per year

23. Chronic ischemic heart disease Progressive heart failure due to ischemic injury, either from: – prior infarction(s) (most common) – chronic low-grade ischemia

24. Sudden cardiac death Unexpected death from cardiac causes either without symptoms or within 1 to 24 hours of symptom onset (different authors use different time points) Results from a fatal arrhythmia, most commonly in patients with severe coronary artery disease

25. Acute coronary syndrome is applied to three catastrophic manifestations of IHD: – Unstable angina – Acute MI – Sudden cardiac death