1. How are synaptic vesicles clustered? Daniel Gitler, Department of Physiology and Cell biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev

2. Presynaptic terminal Postsynapticterminal Gitler et al., J Neurosci 2004

3. Vesicles redistribute into the axon when synapsins are ablated 500 nm Orenbuch et al., J Neurosci 2012

4. Measuring vesicle mobility Darcy at al. 2006 Orenbuch et al., J Neurosci 2012

5. Model for vesicle clustering

6. Synapsins are ATP binding proteins Esser et al., 1998 Crystalographic structure of ATP bound to the central domain of synapsin I Do mutations in ATP binding sites affect clustering and mobilization of vesicles?

7. Other topics Does mobilization of reserve vesicles require endocytosis? The basis for epilepsy in the synapsin TKO mice and in cases of human familial epilepsy linked to synapsin The possibility of a functional interaction between synapsin and alpha-synuclein, a protein involved in Parkinsons disease