1. Sulfonamides:- 1)Oral absorbable – Short, intermediate, long 2)Oral non – absorbable 3)Topical Short: Sulfacytine, Sulfisoxazole, Sulfamethizole Intermediate: Sulfadiazine, sulfamethoxazole, sulfapyridine Long: Sulfadoxine Pyrimidines: Trimethoprim - intermediate

3. Uses: 1)Oral absorbable: UTI eg. Sulfisoxazole 1gm qid, sulfadiazine + pyrimethamine – acute toxoplasmosis (1gm qid) + 75mg. The 25mg od. Folinic acid - Sulfadoxine + pyrimethamine – malaria 2)Oral non-absorbable: Sulfasalazine, - ulcerative colitis, enteritis, inflammatory bowel disease 3)Topical: sodium sulfacetamide – bacterial conjunctivitis, trachoma

4. Mafenide : ADR: hypersensitivity urinary tract hematopoietic TMP – SMX Sequential blockade

5. Why TMP is combined with SMX? Sequential blockade. PK: 1 (80 mg) : 5 (400 mg) Plasma concentration: 1: 20. Perfect synergism

6. Acute Otitis Media GI Infections Respiratory Tract Infections Urinary Tract Infections (UTIs) Brucellosis Burkholderia Infections

7. Cholera Cyclospora Infections Granuloma Inguinale (Donovanosis) Isosporiasis Listeria Infections Mycobacterial Infections Nocardia Infections Pertussis

8. Plague Pneumocystis jiroveci (Pneumocystis carinii) Pneumonia Toxoplasmosis Typhoid Fever and Other Salmonella Infections Wegener's Granulomatosis Whipple's Disease