1. ISO 9001 COMPANY Dehumidification in the Pharma Industry Solutions from : #1 in Dehumidification.... Worldwide pt. adhi trikarya mandiri Rukan Artha Gading Niaga Blok D No. 17 Kelapa Gading, Jakarta 14240 Telp : (62-21) 4584 4310-12, 4584 6579 - Fax : (62-21) 4584 6578 Website : www.adhitrikarya.co.id - E-mail : marketing@adhitrikarya.co.id

2. ISO 9001 COMPANY Pharmaceuticals Some Typical problems ä Disintegration ä Chemical reactions leading to decomposition, shorter shelf life ä Non-uniform coating ä Caking/lumping and agglomeration Moisture is your hidden enemy!

3. ISO 9001 COMPANY Effects of high humidity ä Increased activity of micro organisms ä Deteriorated characteristics of hygroscopic materials

4. ISO 9001 COMPANY One chemical engineer’s headache Hygroscopic nature of Aspirin prevents adhesion, reduces shelf life and potency Solution: Control of humidity

5. ISO 9001 COMPANY Tablets Dry granulation methods Dispensing of trays Drying room MixingWeighing Compression Milling Mixing Tablet compression Packing

6. ISO 9001 COMPANY Tablets/Capsules/Granules Wet granulation methods WeighingPreparation of solution FluidMixing and bed dryerMilling Milling MIXING TabletCapsuleGranule compressionfillingfilling COATING

7. ISO 9001 COMPANY Typical climatic requirement standards 1.Effervescent tablets 90°F and 15% RH 2.Tablet coating 80°F and 5% – 30% RH 3.Tablet compressing 70°–80°F and 10% – 30% RH 4.Penicillin packaging 80°F and 5% – 15% RH 5.Capsule storage 75°F and 35% – 40% RH 6.Powder milling 80°F and 35% RH