1. AfCS-Nature Molecule Pages: The AfCS M&E Office Perspective Patrick J Casey

2. The AfCS M&E Office Team Sharon Brown, Staff Assistant/Office Manager Ashley Butler Brossoie, Scientific Editor AfCS/Nature Editorial Board (25+ members) Based at Duke University in the Heart of Carolina

3. The M&E Office Management Sharon Brown Correspondence with Members  Issue author invitations  Maintain registration records,  Maintain historical data  Answer queries Molecule Pages  Track authorship  Communicate with Editorial Board Protein List  Add new proteins  Maintain synonyms lists

4. Scientific Editing at AfCS Ashley Butler Brossoie Reports, Protocols  Edit AfCS reports  Edit procedure, solution, and ligand protocols  Create/update protocol templates and style guide Molecule Pages  Initial assessment of MPs  Final edit of MPs  Edit/review MP instructions, letters, templates, and tools

5. Molecule Pages Database Contains 3,800 molecules at present  1600+ have assigned authors  800+ authors New molecules added through many routes  Editorial Board recommendations  AfCS lab/committee recommendations  AfCS Member recommendations  Recommendations from scientists through Signaling Gateway Web site

7. Past and Future Goals of the M&E Office Goal for 2003 - 2004  Publish the first full Molecule Pages Goal for 2004 - 2005  Publish a whole lot more Molecule Pages

8. Potential Impediment to Our Goal Many authors committed years ago to effort; would they still participate?

9. Potential Impediments to Our Goal Many authors committed years ago to effort; would they still participate? Solution  Formal re-invitation from NPG

14. Magic Button

15. AfCS/Nature Editorial Process London/NPGDuke Editorial board San DiegoReferees Authors hosting

16. Pat Casey, Duke (Chair) Ken Harden, UNC-Chapel Hill (Vice Chair)GPCRs Joe Albanesi, UT-SouthwesternMyosins/cytoskeletal Cathy Berlot, Weis Institute G proteins and effectors Michael Brownstein, NIHGPCRs Bill Catterall, Univ. of WashingtonIon channels Paul Dawson, Wake ForestTransporters Michael Dean, NCIABC transporters Haian Fu, EmoryPhosphoprotein binding partners James Garrison, Univ. of Virginia G protein β, γ subunits and targets Michael Graziano, Schering PloughGPCRs Donald Gullberg, Univ. of BergenIntegrins, laminins, cell surface Robin Irvine, CambridgePI-metabolizing enzymes Jack Keene, DukeRNA binding proteins John Kyriakis, HarvardProtein kinases Maurine Linder, Wash. U. Lipid modification/trafficking Randy Moon, Univ. of WashingtonWnt/Frizled pathway Mary Moore, BaylorNuclear import Ben Neel, Harvard Protein phosphatases Leslie Parise, UNC-Chapel HillIntegrins Richard Premont, Duke Targets of small G proteins David Siderovski, UNC-Chapel HillRGS proteins and regulators Jeremy Thorner, UC-BerkeleyIntracellular kinases and signaling Michael White, UT-SouthwesternRas/Rac/Rho/Rap Tom Wilkie, UT-SouthwesternTarget of heterotrimeric G proteins AFCS/Nature Editorial Board

17. Editorial Workflow DukeLondon/NPGSan DiegoReferees Authors Duke Author contract submission Authors Duke verification peer review subediting accepted MP posting chasingconfirmation revision Annual revision & peer review Editorial Board conflict resolution Ed. Board Invitation

18. The AfCS Membership and Editorial Office We’re there for you!

19. The AfCS Membership and Editorial Office We’re there for you!