1. Components of our Circulatory System

2. What we will be looking at: Why do multi-cellular organisms need and internal transport system? List the functions of our circulatory system What is plasma and what is in it? Compare erythrocytes, leukocytes and thrombocytes in terms of: Structure, function, where are they made, numbers in blood, lifespan Describe the formation of a blood clot Compare arteries, capillaries and veins in terms of: structure, valves, direction of blood flow, what they carry and relative blood pressure Blood types and blood transfusions What is agglutination and why is it dangerous? What blood type and why are the universal donors and recipients?

3. Why do multicellular organisms need an internal transport system? Cells on the inside don’t have direct contact with external cells and therefore need to be supplied with oxygen and nutrients and to get rid of carbon dioxide and wastes

4. List functions of the circulatory system 1) transport oxygen/carbon dioxide 2) transport nutrients/wastes 3) regulate temperature 4) transport hormones 5) transport our immune system

5. What is plasma and what is in it?

6. Blood Plasma The liquid portion of the blood Makes up about 55% of total blood volume Mostly water 90% and the other 10% is dissolved materials like- protein, glucose, vitamins, gas and wastes

7. What makes up the rest of the blood volume? The other 45 % of your blood is made of: White blood cells(Leukocytes), Red blood cells(Erythrocytes) and Platlets (thrombocytes).

8. Red Blood Cells (Erythrocytes)

9. Red Blood cells inside a blood vessel

10. Hemoglobin

11. Red Blood Cells Donut shaped (greater surface area) They don’t have a nucleus at maturity to allow more room inside the cell to carry oxygen - hemoglobin (about 280 million per red blood cell) They are made in your bone marrow There is about 4.5 to 5.5 million/ml of blood They last about 120 days

12. When the red blood cells do eventually break down the hemoglobin molecules are released. The iron from the hemoglobin is recycled by the bone marrow and the Heme pigment is removed by the body through our feces (giving our feces its color)

13. Anemia Normally caused by an iron deficiency due to poor iron absorption by the body or lack of iron in the diet or excessive bleeding This lack of iron causes less hemoglobin to form in red blood cells Less oxygen is transported to the mitochondria for respiration Lack of energy results

14. White Blood Cells (Leukocytes)

16. Types of white blood cells

18. White blood cells These are your defense army against foreign invaders (IMMUNE SYSTEM) to fight against infection Five different types with slightly different jobs that can be identified by their nucleus shape after staining Made in the bone marrow About 5000 to 9000 /ml Some last hours and others a lifetime

19. Leukemia

20. Leukemia- what is it? Leukemia is cancer that originates in the bone marrow, the soft, spongy inner portion of certain bones, and in which the malignant cells are white blood cells (leukocytes). Acute myelogenous leukemia is a malignancy that arises in either granulocytes or monocytes which are white blood cells that battle infectious agents throughout the body.

21. Symptoms of Leukemia The patient's bone marrow makes too many blast cells (immature white blood cells). Normal blast cells turn into a type of white blood cell called granulocytes, but the leukemia blast cells do not. At the same time, the marrow cannot grow enough normal red blood cells, white blood cells, and platelets.

22. Platlets (Thrombocytes)

24. Platelets Irregular shaped cells Contain NO nucleus at maturity Help to clot blood Made in bone marrow About 250 000/ml Last about 10 days

25. Blood clotting As platelets circulate through the blood stream they may encounter a damaged blood vessel causing the platelets to rupture This releases a chemical which sets off a chemical chain reaction ultimately forming a web made of fibrinogen to clot the broken blood vessel

27. Arteries, Capillaries and Veins

28. Arteries/capillaries/veins

30. Arteries Very thick Outer Coat-smooth muscle-elastic layer- lining There are NO valves in them They bring blood Away from the heart They carry oxygen (ONE exception in the pulmonary artery) High blood pressure

31. Veins

33. Similar structure to arteries but thinner They DO contain one-way valves They bring blood towards the heart They carry Carbon Dioxide (with the exception of the pulmonary vein) The blood is under low pressure in them

34. Varicose Veins Due to the low blood pressure there are one way valves to prevent the backflow of blood Sometimes the blood pools at these valves causing the vein to get larger=varicose veins

37. Treatment for Varicose Veins Vein stripping Injections New veins are able to reroute and grow around the removed veins

38. Capillaries

40. Very thin walled to allow for diffusion Come in contact with cells Acts as a bridge between arteries and veins Contain NO valves Carry both oxygenated and deoxygenated blood

41. Blood Types and Transfusions

42. Agglutination When different blood types are mixed antibodies may latch onto the introduced blood type and cause clumping/clotting (agglutination) of the blood This can go on to cause death!

44. AB+ blood type is considered the UNIVERSAL RECIPIENT because they would have NO antibodies against any blood types and therefore could receive any blood type O- blood type is considered the UNIVERSAL DONOR because there are no antigens on the donated blood for any antibodies to recognize or bind onto and therefore all blood types could receive O-