1. Update on Genetic Links to HCV Clearance Todd Wills, MD ETAC Infectious Disease Specialist HEPATITIS C TREATMENT EXPANSION INITIATIVE MULTISITE CONFERENCE CALL FEBRUARY 20, 2013

2. DL Ge et al. Nature 461, 399-401(2009) Percentage of SVR by genotypes for IL-28B region

3. Clinical Correlates of IL28B CC Genotype Spontaneous Clearance of HCV infection Improved response to interferon based treatment Faster progression to cirrhosis in HIV infection Treatment effect less significant with HCV direct acting antivirals Potential role in treatment decisions in acute HCV infection Barreiro P et al. J Infect Dis. 2011;203:1629-1636 DL Ge et al. Nature 461, 399-401(2009)

4. Duggal, P. et al. Annals of Internal Medicine. 158(4):235-245, February 19, 2013. Genetic Loci Associated with Spontaneous Clearance of HCV

5. Conditional Analysis of Allele Effect – HLA and IL28B Duggal, P. et al. Annals of Internal Medicine. 158(4):235-245, February 19, 2013.

6. Clinical Correlates of HLA loci (DQB1*03:01 ) Increased rate of HCV spontaneous clearance Does not effect response to treatment May be associated with preserved HCV specific proliferative CD4 response Duggal, P. et al. Annals of Internal Medicine. 158(4):235-245, February 19, 2013.