Download presentation
Presentation is loading. Please wait.
Published byCamron Harrison Modified over 9 years ago
1
Dopamine in CNC Abdulelah Nuqali Intern
2
Overview Introduction Biochemistry Dopamine receptors Dopaminergic pathways Summary 2
3
Introduction Dopamine belongs to the family of catecholamines Hormones Epinephrine and Norepinephrine (other catecholamines) are derived from Dopamine Significant role in learning, goal-directed behavior, regulation of hormones, motor control 3
4
4
5
Synthesis DOPA is converted so rapidly into Dopamine 5 Rate Limiting Step
6
Metabolism In primates and human – HVA major metabolite Accumulation of HVA in brain or CSF used as index of function of dopaminergic neurons 6
7
Dopamine Receptors D 1 – like family: – Includes subtypes D 1 and D 5 – Activation is coupled to G αs ; activates adenylyl cylcase which leads to increase in concentration of cAMP D 2 – like family: – Includes D 2, D 3 and D 4 – Activation is coupled to G αi ; inhibits adenylyl cyclase leading to decrease in concentration of cAMP 7
8
Dopamine Receptors 8
9
9
10
10
11
Dopamine Receptors 11
12
Dopaminergic Neurons 12
13
Dopaminergic Pathways Mesolimbic Pathway Mesocortical Pathway Nigrostriatal Pathway Tuberoinfundibular Pathway Incertohypothalamic Pathway Medullary Periventricular Retinal Olfactory bulb 13
14
Dopaminergic Pathways 14 Moore et al. 1978
15
Significance of Dopaminergic Pathways Mesolimbic Pathway – Associated with pleasure, reward and goal directed behavior Mesocortical Pathway – Associated with motivational and emotional responses Nigrostriatal Pathway – Involved in coordination of movement (part of basal ganglia motor loop) 15
16
Summary Neurotransmitter that acts as a modulator 2 family of receptors for dopamine 3 main pathways of action 16
17
17
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.