1. PDGF PDGFR Mitogenesis Actin Reorganization Figure 1. PI3K Raf-1 MEK c-fosc-jun MAP Kinase Erk Rac Rho Ras Grb2 mSos

2. - + + + + + + 4 5 6 7 8 9 10 111 2 3 0 115 205 295 385 475 565 655 mM NaCl Balb membranes plus fractionsBalb PDGF-BB B+K Figure 2. PDGF  R 116 205 97 66

3. Figure 3. 1 2 3 4 5 6 7 8 - + + + + + + + - - 0 205 295 0 205 295 PDGF-BB mM NaCl  -Syp + + + PDGF  R 200 97.4 68

4. Figure 4. AB CD

5. Table 1. Preatment of Balb and Kbalb cells with sodium vanadate prior to PDGF-BB stimulation: Correlation with PDGF-  R kinase activity and cell phenotype. Cell typeVO 4 PDGF-  R kinase activity Phenotype Balb KBalb - - + + + + - + Untransformed fibroblast Transformed fibroblast Fibroblast-like

6. Figure 5. P FAK V T  Ras Rac Rho PI3K Pak ROK Ras MAPK cascade