1. Reporter: Qinglan Liu Supervisor: Prof. Yong Huang 2016-01-25

2. Introduction  General directing group 2 σ-electron donating groups: pyridyl, acetyl, and amide etc Org. Chem. Front. 2015, 2, 1107

3. 3 Introduction  alkenyl and alkynyl functional groups as directing group J. Org. Chem. 1993, 58, 5386 J. Am. Chem. Soc. 2008, 130, 5636 Chem. Commun. 2008, 44, 6013 J. Am. Chem. Soc. 2012, 134, 5738 Chem. –Eur. J. 2014, 20, 385

4. 4 Introduction

5. 5 A potent directing group to activate C−H bonds with palladium complexes As an addition acceptor to form cyclic products. Introduction

6. 6 Partner I:alkynes Angew. Chem. Int. Ed. 2015, 54, 3783

7. 7 No reaction J. Am. Chem. Soc. 2012, 134, 6124 Partner I:alkynes

8. 8

9. 9

10. 10 bulky ligands and substituents on the alkynyl carbon Partner I:alkynes

11. 11 Partner II: double bonds One –pot can also be conducted

12. 12 Partner II: double bonds

13. 13 benzoxazinone Tetrahedron 2015, 71, 4522 Partner II: double bonds

14. 14 Benzoxazinone ring is nearly planar and that the 4-phenyl group is twisted almost perpendicular to the benzoxazinone plane. Partner II: double bonds

15. 15 Partner II: double bonds

16. 16 sp 3 C-H activation CMD C-H activation Partner III: Intramolecular insertion

17. 17 Peterson olefination Partner III: Intramolecular insertion

18. 18 Partner III: Intramolecular insertion

19. 19 Partner III: Intramolecular insertion

20. 20 Partner III: Intramolecular insertion

21. Summary 21

22. Thanks for Your Attention ！ 22