1. NCRR Overview Center for Bioelectric Field Modeling, Simulation and Visualization Chris Johnson (PI) Rob MacLeod (Co-PI) Chuck Hansen (Co-PI) University of Utah

2. NCRR Overview Logistics Goals of the EAB Meeting Mock Site Visit Dinner – Bangkok Thai – 6:00 p.m. Lunch – Stoneground Pizza and Pasta Transportation Connectivity Schedule

3. NCRR Overview Schedule Monday March 4 30 8:30-9:00Breakfast, Center Highlights 20 9:00-9:20BioPSE 10 9:20-9:30Questions 60 9:30-10:30BioPSE Demos 10 10:30-10:40Break 20 10:40-11:00Modeling 20 11:00-11:20Visualization 10 11:20-11:30Questions 20 11:30-11:50Simulation 10 11:50-12:00Questions 60 12:00-1:00Lunch and Executive Session 30 1:00-1:30Software Engineering and Release/Documentation 10 1:30-1:40Questions 30 1:40-2:10Collaborators 60 2:10-3:10Research Posters and Demos 20 3:10-3:30Break 15 3:30-3:45Service/Training/Dissemination 75 3:45-5:00Meeting with Center Admin 6:00Dinner Research Demos - GENESIS and BioPSE - Matlab interface in BioPSE - Cardiowave - Defibrillation electrodes - Quadratic/linear elements - Tank FEM - Focusing inversion - Tikhonov regularization - Inverse EEG - Map3d - Surgical planning visualization Research Posters - MRI amplitude correction - MRI/EPI geometric correction - Adaptive mesh Generation - Multiigrid methods - MEG volume currents

4. NCRR Overview Center Time Line Started - September 15, 1999 Fully Staffed - May, 2000 1 st Code Release – February, 2001 1 st EAB Meeting – April, 2001 432 BioPSE Downloads – Feb, 2002 4 th Code Release – March, 2002 2 nd EAB Meeting – March, 2002 Renewal Site Visit – March, 2002

5. NCRR Overview Aims and Objectives Develop and Implement : An integrated, extensible, problem-solving environment (BioPSE) Bioelectric field simulation tools Geometric modeling tools Visualization methods and tools

6. NCRR Overview Visualization Excellence IEEE Visualization 2001 Best Paper Award IEEE Visualization 2001 Best Panel Award IEEE Visualization 2000 Best Panel Award IEEE Visualization `99 Best Paper Award IEEE Visualization `98 Best Paper Award ACM Volume Visualization `98 Best Paper Award IEEE Visualization `97 Best Panel Award

7. NCRR Overview Research Overview Model

8. NCRR Overview Modeling Highlights Development: Interated image processing, segmentation, tesselation tools Parametric representations Research Hierarchical meshes Modeling fitting Time dependent meshes

9. NCRR Overview Research Overview Sim

10. NCRR Overview Simulation Highlights Computational infrastructure Adaptive/multi-level techniques –Multigrid and adaptive FE Inverse solution approaches –Focusing inversion, lead field Numerical methods –PETSc Validation EEG head phantom ECG torso tank

11. NCRR Overview Device Design: Defibrillation

12. NCRR Overview Research Overview Vis

13. NCRR Overview Visualization Highlights Created: Several new BioPSE and map3d developments Specialized interactive visualization for bioelectric fields Portable software using modern standards High-end approaches for tomorrow’s desktops

14. NCRR Overview Research Overview Core BioPSE

15. NCRR Overview BioPSE Model SimVis Core BioPSE Integration Extensibility Program Design Interactivity Portability User Interface Data Management

16. NCRR Overview Elements of BioPSE Visual programming

17. NCRR Overview Open Source Software BioPSE, SCIRun, and map3d available as open source www.sci.utah.edu

18. NCRR Overview Software Releases BioPSE Version 1.4 March, 2002 Open Source Target platforms: –Irix, Linux –Single and multiprocessors Map3d Version 5.3 September, 2001 Target platforms: – Irix, Linux, Windows

19. NCRR Overview Center Organization Chart External Advisory Board Technical Manager ( D. Weinstein) Collaborators Directors (C. Johnson and R. MacLeod) Modeling Research (R. MacLeod, Ph.D.) Visualization Research (C. Hansen. Ph.D.) Simulation Research (C. Johnson, Ph.D.) PSE Research (S. Parker, Ph.D.) Software Engineering Marty Cole Administrator (A. Betancourt) Media Specialist (R. Coffey) Systems (R. Cummins) Associate Director ( Greg Jones )

20. NCRR Overview Center Personnel Chris Johnson Rob MacLeod Chuck Hansen Steve Parker Dana Brooks Dave Weinstein Allyne Betancourt Oleg Portniaguine Ted Dustman Blythe Nobleman McKay Davis Xinlong Wang Marty Cole Mike Calahan Laura Traynor Chris Butson Alexei Samsonov Kris Zyp Gordon Kindlman Robert Van Uitert Yesim Serinagaoglu Alireza Ghodrati Darby Brown Bryan Worthen Daniel Perry

21. NCRR Overview Collaborator Overview 3D Cardiac Mapping Taccardi Cortical Mapping McCarley Neurosurgery Modeling and Visualization Kikinis Inverse ECG Rudy Cardiac Propagation Henriquez Clinical Mapping Triedman Model SimVis Core BioPSE Inverse EEG Leahy EEG/MEG Jukka Electromechanical McCulloch

22. NCRR Overview Service, Training, and Dissemination Disseminate or Provide: State-of-the-art software and documentation developed within the Center –New software releases and large documentation effort An on-line database of geometric models and simulation data –New torso and head models on-line Short courses on the use of Center software tools –BioPSE short course planned for May, 2002 Workshops on bioelectric field research –Minisymposium on Computational Bioelectric Fields – SIAM 50 th Anniversary Conference

23. NCRR Overview

24. NCRR Overview Web Statistics 500,000 total hits 30,000 total visits 10,000 unique visits 500,000 minutes (347 days) spent surfing our site Average of 16 minutes per visit

25. NCRR Overview Leadership NSF Workshop on Computational Science Co- Chairs, Chris and Randall Bramley, 2001 IEEE Visualization `2000 Conference Co-Chairs, Chris and Chuck DOE Workshop on PSEs Co-Chairs, Steve, Chris, and Rick Stevens, 1999 NIH Biomedical Computing Advisory Committee to the Director: NIH Biomedical Information Science and Technology Initiative, Chris, 1999

26. NCRR Overview Leadership 5 Journal Editorial Boards 8 Advisory Boards (3 NCRRs) 8 Chair: National Conferences and Workshops 13 Keynote or Plenary Presentations (6 more scheduled) 33 Conference Program or Organizing Committees 47 Peer Review Papers and Book Chapters

27. NCRR Overview More Information www.sci.utah.edu/ncrr crj@cs.utah.edu

28. NCRR Overview Schedule Monday March 4 30 8:30-9:00Breakfast, Center Highlights 20 9:00-9:20BioPSE 10 9:20-9:30Questions 60 9:30-10:30BioPSE Demos 10 10:30-10:40Break 20 10:40-11:00Modeling 20 11:00-11:20Visualization 10 11:20-11:30Questions 20 11:30-11:50Simulation 10 11:50-12:00Questions 60 12:00-1:00Lunch and Executive Session 30 1:00-1:30Software Engineering and Release/Documentation 10 1:30-1:40Questions 30 1:40-2:10Collaborators 60 2:10-3:10Research Posters and Demos 20 3:10-3:30Break 15 3:30-3:45Service/Training/Dissemination 75 3:45-5:00Meeting with Center Admin 6:00Dinner Research Demos - GENESIS and BioPSE - Matlab interface in BioPSE - Cardiowave - Defibrillation electrodes - Quadratic/linear elements - Tank FEM - Focusing inversion - Tikhonov regularization - Inverse EEG - Map3d - Surgical planning visualization Research Posters - MRI amplitude correction - MRI/EPI geometric correction - Adaptive mesh Generation - Multiigrid methods - MEG volume currents