1. Experiment 6: EXTRACTION of ANALGESICS

2. Objectives  To learn the technique of acid-base extraction.  To separate aspirin from acetaminophen using the extraction technique.  To learn the techniques of drying organic solvents and vacuum filtration.  To analyze the purity of the aspirin and acetaminophen samples using HPLC analysis.

3. ANALGESICS IN GOODY’S POWDERS 500 mg/powder 325 mg/powder

4. SEPARATORY FUNNEL TECHNIQUE

5. ACID–BASE EXTRACTION OF ASPIRIN AND ACETAMINOPHEN

7. THEORETICAL RECOVERY  For this experiment, we dissolved 2 Goody’s powders in 25mL of ethyl acetate.  In each Goody’s powder, there is 0.500g of aspirin and 0.325g of acetaminophen.  Theo. Recovery: 0.500g per powder X 2 powders = ?g of Aspirin 0.325g per powder X 2 powders = ?g of Acetaminophen

8. SAFETY CONCERNS  Acetone and ethyl acetate are extremely flammable! Wear safety goggles at all times and use extreme caution when heating!

9. WASTE MANAGEMENT  The drying agent (MgSO 4 ) and filter paper should be placed in the container labeled “MgSO 4 Waste” provided in the hood.  The aqueous acidic phase left after filtering off aspirin should be placed in a bottle in the hood labeled "Acidic Waste (Aspirin)”.