1. WBC Differential After LPS Neutros Figure 1

2. Table 1. Leukocyte enrichment as assessed by flow cytometry. Enrichment Method TimeAfterEndotoxin 0 Hrs2 Hrs6 Hrs Ficoll-Dextran Granulocytes96 ±1 5 96 ±2 5 99 ±1 5 RossetteSep T-cells95 ±8 1,2 96 ±6 2 86 ±3 2 RossetteSep Monocytes80 ±5 3 QNS 4 67 ±9 3 1 Data represent the Mean ±SEM; 2 percent side scatter low, CD2 high; 3 percent side scatter intermediate, CD33 high; 4 quantity not sufficient for microarray analysis due to monocytopenia (see Table 1); 5 percent side scatter high, CD66b high

3. Hierarchical Cluster Analysis Figure 2

4. Monocytes Neutrophils T-cells MHC Class II six hrs post endotoxin Figure 3

5. Probe Set Numbers at FDR = 0.1% Leukocytes (previous study) 5,093 Leukocytes8,358 Neutrophils2,531 Monocytes1,095 T-cells 456 Table 2

6. Monocytes Neutrophils Figure 4a Figure 4b Figure 4c ??

7. Neutrophils, 6 hrs Figure 5a

8. Monocytes, 6 hrs Figure 5b

9. T-cells, 6 hrs Figure 5c

10. Neutrophils, 6 hrs Figure 6a

11. Monocytes, 6 hrs Figure 6b

12. T-cells, 6 hrs Figure 6c

13. Neutrophils Figure 7a

14. Monocytes Figure 7b

15. T-cells Figure 7c

16. Probe Set MonocytesNeutrophilsT-Cells TP53 -1.6-3.21.2 MDM2 --- -1.3 RPL5 -1.7-3.3--- RPL11 -1.3-3.3--- RPL23 -1.5-2.6--- RPL26 --- MRPL41 ----1.9--- Nucleolin -1.3-2.6--- Fold Up/Fold Down for p53 regulators Table 3

17. RPL/RPS MonocytesNeutrophils T cells Figure 8