1. UUU... UUG GAC AUA AAU GGG F O L D I N G --- --- --- --- --- --- --- ACC AGG GCU AAU AGU UUA GCG ACU AUC... AAC T R A N S L A T I O N --- --- --- --- --- --- --- --- --- --- --- m-RNA base Codons Instructions: The genetic code is the set of rules by which information encoded in genetic material (DNA or RNA sequences) is translated into proteins (amino acid sequences) by living cells. Specifically, the code defines a mapping between trinucleotide sequences called codons and amino acids. For a given codon (3 nucleotide sequence) to find the amino acid coded 1.Start with the first nucleotide center blue circle 2.Follow the second nucleotide from red circle 3.Follow the third nucleotide from green circle AAA codes for the amino acid Lysine (K) Example: GGU GAA AAU GAG ACU AUU UGU G E N E T I C --- --- --- --- --- --- --- CRACK THE FOLLOWING CODES 1.2.3.... AUA... AUU AAC UUC... CGG AUG GCA ACG AUU UGU UCA B I O I N F O R M A T I C S --- --- --- --- --- --- --- CCU AGG AUC... AAC P R I O N --- --- --- --- --- 4. Computational Biology Research Group Department of Microbiology, University of Washington, Seattle http://www.compbio.washington.edu/

2. AlanineAla A ArginineArg R AsparagineAsn N Aspartic acidAsp D CysteineCys C Glutamic acidGlu E GlutamineGln Q GlycineGly G HistidineHis H IsoleucineIle I LeucineLeu L LysineLys K MethionineMet M PhenylalaninePhe F ProlinePro P SerineSer S ThreonineThr T TryptophanTrp W TyrosineTyr Y ValineVal V P A S I F I C S C I E N C E C E N T E R ___________________ ___________________ _______________ http://protinfo.compbio.washington.edu/prostring/ For online version visit: C H A R L E S D A R W I N ______________________ _________________ F R A N C I S C R I C K ______________________ ________________ Instructions: Amino acids are the structural units that make up proteins. They all have different atomic composition and thus structures. Using the table on the right decipher the following protein hieroglyphs. R I C H A R D F E Y N M A N ______________________ ____________________ P A S I F I C

3. Computational Biology Research Group Department of Microbiology, University of Washington, Seattle http://www.compbio.washington.edu/ ____________________________________________ Instructions: Write your name in both sections A and B and translate it into the “Genetic Code” and the “Protein Hieroglyph”. When you finish let us check it…