1. Parkinson’s Test Device Development Tiffany Feltman Erin Sikkel

2. Parkinson’s Disease A disorder of the brain that occurs when the neurons in the substantia nigra die or become slightly impaired. A disorder of the brain that occurs when the neurons in the substantia nigra die or become slightly impaired. These neurons usually produce the chemical dopamine which allows for smooth, coordinated functioning of the muscles in the body. These neurons usually produce the chemical dopamine which allows for smooth, coordinated functioning of the muscles in the body. Some of the main symptoms are tremors, slowness of movement, rigidity, and difficulty with balance. Some of the main symptoms are tremors, slowness of movement, rigidity, and difficulty with balance. These problems can lead to a deeper state of the disease which includes small handwriting, stiff facial expression, shuffling walk, muffled speech, which all lead to depression. These problems can lead to a deeper state of the disease which includes small handwriting, stiff facial expression, shuffling walk, muffled speech, which all lead to depression.

3. Parkinson’s Disease Affects 1.5 million Americans Affects 1.5 million Americans Affected after the age of 65, but roughly 15% are diagnosed under the age of 50. Affected after the age of 65, but roughly 15% are diagnosed under the age of 50. According to these demographics, the market size for this project is great. According to these demographics, the market size for this project is great. The market size for this product would be high since it will give a greater insight into the brain stimulation and allow doctors and researchers to find out more about the disease and how to treat it. The market size for this product would be high since it will give a greater insight into the brain stimulation and allow doctors and researchers to find out more about the disease and how to treat it.

4. Competition Activa Tremor Control System Activa Tremor Control System Delivered by an implanted medical device similar to cardiac pacemakers, that uses electrical stimulation to block the brain signals that cause tremors. Delivered by an implanted medical device similar to cardiac pacemakers, that uses electrical stimulation to block the brain signals that cause tremors. Stimulates targeted cells in the thalamus through surgically implanted electrodes in the brain and are connected to a neurostimulator implanted near the collarbone. Stimulates targeted cells in the thalamus through surgically implanted electrodes in the brain and are connected to a neurostimulator implanted near the collarbone. The electrical stimulation can be non-invasively adjusted to fit the patient’s needs. The electrical stimulation can be non-invasively adjusted to fit the patient’s needs.

5. Competition Ventro-intermediate (Vim) nucleus of thalamus Ventro-intermediate (Vim) nucleus of thalamus Common target for the treatment of tremors as it is suggested to play an important role in the occurrence of disease. Common target for the treatment of tremors as it is suggested to play an important role in the occurrence of disease. By using conventional MR imaging, metabolic alterations of the contralateral thalamus can be seen. By using conventional MR imaging, metabolic alterations of the contralateral thalamus can be seen. It reduces the tremors associated with Parkinson’s Disease, but unable to help with other symptoms It reduces the tremors associated with Parkinson’s Disease, but unable to help with other symptoms

6. Competition Pallidotomy Pallidotomy The Globus pallidus is a pale-appearing spherical area in the brain. It is part of the lentiform nucleus, which is part of the striate body, a component of the basal ganglia, which is the large mass of gray matter at the base of the cerebral hemispheres of the brain. The Globus pallidus is a pale-appearing spherical area in the brain. It is part of the lentiform nucleus, which is part of the striate body, a component of the basal ganglia, which is the large mass of gray matter at the base of the cerebral hemispheres of the brain. This part of the brain is lesioned, and has been shown that this may improve the symptoms of tremor, rigidity, and bradykinesia. They believe this is achieved by interrupting the neural pathway between the globus pallidua and the striatum or thalamus. This part of the brain is lesioned, and has been shown that this may improve the symptoms of tremor, rigidity, and bradykinesia. They believe this is achieved by interrupting the neural pathway between the globus pallidua and the striatum or thalamus.

7. Problem: Original devices are hard for patients to use Too confusing Too confusing Too hard to use Too hard to use

8. Primary Objective Create a device that is easier to use for people with motor disorders Create a device that is easier to use for people with motor disorders Have a device that is compatible with the software being used for diagnosis Have a device that is compatible with the software being used for diagnosis

9. Solution Description IRB filed to interact with patients and see their needs IRB filed to interact with patients and see their needs Research joysticks and what would be the best option Research joysticks and what would be the best option

10. Proposed Hardware Using one of the joysticks that is currently used, it needs to be redesigned in order to make it easier to use Using one of the joysticks that is currently used, it needs to be redesigned in order to make it easier to use

11. Timeline

12. Short Term Goals Research into the different joysticks that can be used Research into the different joysticks that can be used Meet with the graduate students we’re working with Meet with the graduate students we’re working with

13. Ultimate Project Goals Quantify ways in which Parkinson’s patients respond to stimulation therapy. Quantify ways in which Parkinson’s patients respond to stimulation therapy. Create a software program for use with a laptop computer that a doctor could bring to the clinic or operating room in which we have a patient use a joy- stick to track an object on the screen that moves around and measures the time it takes to follow that object around the screen. Create a software program for use with a laptop computer that a doctor could bring to the clinic or operating room in which we have a patient use a joy- stick to track an object on the screen that moves around and measures the time it takes to follow that object around the screen. Able to output that timed response in some sort of excel file etc. Able to output that timed response in some sort of excel file etc.