1. -0.8 -0.6 -0.4 -0.2 0 0.2 0.4 05101520253035 -0.8 -0.6 -0.4 -0.2 0 0.2 0.4 0123456789 Supplementary Fig. 1 APACHE II score ( transformed) SOFA score (transformed) FT3(pmol/L)/FT4(pmol/L) ratio (transformed) 0.493 (3.00) FT3(pmol/L)/FT4(pmol/L) ratio (transformed) (3.00) 0.493

2. 0 20 40 60 80 100 020406080100120 MMI(mg) 0 20 40 60 80 100 120 140 160 180 2004006008001000120014001600 PTU(mg) FT3(pmol/L) 0 20 40 60 80 100 2004006008001000120014001600 PTU(mg) FT3(pmol/L) FT4(pmol/L) Supplementary Fig. 2

3. 1600 1800 2000 2200 2400 2600 2800 3000 05101520253035 1600 1800 2000 2200 2400 2600 2800 3000 0123456789 HC equivalent dose (mg) of CS (transformed) APACHE II score (transformed) SOFA score (transformed) (20) (5000) Supplementary Fig. 3 (5000) (20)