2. When Cells Divide Mitosis By: Your teacher!© 1998

3. About Mitosis What is mitosis? Why is it important? The Phases of Mitosis Test your knowledge Review

4. What is Mitosis? How cells with nuclei reproduce One cell divides into 2 identical daughter cells. 5 stages (I.P.M.A.T.) 

5. Why Mitosis? Allows multicellular organisms to grow 10 m of DNA in 10 um nuclear diameter Chromosomes = compact DNA & proteins, easy to move - facilitates division versus

6. Phases of Mitosis Interphase Prophase Metaphase Anaphase Telophase

7. Interphase Period I n-between divisions Nuclear membrane present DNA in loose strands for transcription Cell grows, DNA replicates (doubled)

8. Prophase Cell P repares to divide DNA condenses into doubled chromosomes Nuclear membrane disappears Spindle apparatus forms

9. Metaphase Chromosomes move to M iddle Spindle fibers attach at centromere (Kinetochores) Spindle apparatus stretches from pole to pole

10. Anaphase Chromatids move A way to poles Centromere splits  2 kinetochores Each chromosome  2 chromatids Spindle fibers contract pulling kinetochore/chromatid away

11. Telophase Cell T ears in T wo Nuclear membrane forms Chromosomes disperse Cytokinesis  2 identical “daughter” cells Both new cells in interphase

12. Phases of Mitosis Interphase - cell life I n-between divisions Prophase - cell P repares to divide Metaphase - chromosomes move to M iddle Anaphase - chromatids move A way Telophase - cell T ears in T wo

13. What is Mitosis ?

14. How cells with nuclei reproduce One cell divides into 2 identical daughter cells. 5 stages (I.P.M.A.T.)

15. Why Mitosis ? Which of these cells can divide it’s DNA evenly without damaging it?

16. Why Mitosis ? The bottom one! It’s DNA is condensed into chromosomes DNA in the top one cannot be divided

17. What Phase ? Chromosomes lined up in M iddle Spindle fibers attach at centromere (Kinetochores) Spindle apparatus stretches from pole to pole

18. It’s Metaphase! The chromosomes moved to the M iddle!

19. What Phase ? Period I n-between divisions Nuclear membrane present DNA in loose strands for transcription Cell grows, DNA replicates (doubled)

20. It’s Interphase! The cell is I n-between divisions

21. What Phase ? Chromatids move A way to poles Centromere splits  2 kinetochores Each chromosome  2 chromatids Spindle fibers contract pulling kinetochore/chromatid away

22. It’s Anaphase! Chromatids move A way to poles

23. What Phase ? Cell T ears in T wo Nuclear membrane forms Chromosomes disperse Cytokinesis  2 identical “daughter” cells Both new cells in interphase

24. It’s Telophase! Cell T ears in T wo

25. What Phase! Cell P repares to divide DNA condenses into doubled chromosomes Nuclear membrane disappears Spindle apparatus forms

26. It’s Prophase! The cell is P reparing to divide.

27. Mitosis = I.P.M.A.T. I nterphase - cell life I n-between divisions P rophase - cell P repares to divide M etaphase - chromosomes move to M iddle A naphase - chromatids move A way T elophase - cell T ears in T wo