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Published byAlexina Chapman Modified over 9 years ago
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NUCLEOPHILIC SUBSTITUTION REACTION CARBOXYLIC ACID AND ITS DERIVATIVES NUCLEOPHILIC ADDITION to a carbonyl group as the first step
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NUCLEOPHILIC SUBSTITUTION REACTION CARBOXYLIC ACID AND ITS DERIVATIVES Rearrange the pi-bonding electron pair: Move them to the more electronegative oxygen. This maintains the tetravalency of carbon.
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NUCLEOPHILIC SUBSTITUTION REACTION CARBOXYLIC ACID AND ITS DERIVATIVES Since X is a good leaving group, the negative charge on the oxygen will be involved in ejecting the group X and re-establish the C=O bond thus completing the reaction. ELIMINATION OF GROUP X
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NUCLEOPHILIC SUBSTITUTION REACTION CARBOXYLIC ACID AND ITS DERIVATIVES Overall process: Nucleophilic Addition followed by Elimination of X
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