1. Infection

2. Learning objectives To understand how an infection develops To learn about the main groups of pathogenic organisms To introduce examples of pathogens

3. The life of an infection. (Try to explain the graph)

4. The main Pathogens (germs) Bacteria: Prokaryotic organisms that reproduce inside the body and release toxins that harm the body. Responsible for food poisoning, blood poisoning etc.

5. Bacteria contd. Gram + cocci e.g. Staphylococcus aureus responsible for MRSA & Streptococcus pneumoniae responsible for pneumonia Gram –ve cocci: the STD Gonnorhoea and bacterial meningitisAll treatable with antibiotics PenicillinVarious bacilli Escherichia coli Harmless in our lower gut but causes sickness if ingested in food, Salmonella, cholera and bubonic plague.

6. Other bacterial disease Clostridium spp. Cause Botulism (a serious type of food poisoning) and tetanus (lock jaw) a potentially fatal type of blood poisoning. TuberculosisLeprosy (treatable but not curable) Also not very infectiousSyphilis – another STDLyme Disease – spread by a deer tick.

7. Viruses

8. Very smallCannot sustain life on their ownMust develop and reproduce as parasites in cellsKill host cellsHard to treat because they are protected by host cells.

9. Viral life cycle http://www.wisc- online.com/Objects/ViewObject.aspx?ID=SCE4 04

10. Viral diseases Mostly cannot be treated. Many can be prevented by vaccination.Small Pox/ cow pox/chicken poxMeasles and german Measles (Rubella)MumpsCommon cold, InfluenzaHIVnorovirusnorovirus and rotavirus, common causes of viral gastroenteritisrotavirusgastroenteritis

11. Wide a variety of different classes of viruses Depends on whether they have RNA and DNA Depends on life cycle and how they reproduce inside the cell Example of viral classification, the chicken pox virus, varicella zoster (VZV), belongs to the order Herpesvirales, family Herpesviridae, subfamily Alphaherpesvirinae, and genus Varicellovirus. VZV is in Group I of the Baltimore Classification because it is a dsDNA virus that does not use reverse transcriptase.chicken poxvaricella zosterHerpesviridaeAlphaherpesvirinae Varicellovirus

12. Prions These are simple infectious proteins They can only reproduce inside animals where they convert existing proteins to the rogue form. They are currently only known to cause diseases of the nervous system such as mad cow disease and Creuzfeld Jakob

13. Protozoans Single celled Eukaryotes. Most are harmless but some are pathogens: Amoebae: Amoebic dysentery

14. Flagellates The diarrhoea causing Giardia lamblia; Sleeping sickness Trypanosoma

15. Sporozoans: Malaria caused by Plasmodium

16. Toxoplasmosis Which can cause severe foetal deformities if it infects pregnant women.

17. Fungi Athletes footThrush Other skin infections such as Jock itch and ringworm Infections of the toenail.

18. Multicellular parasites Helminthic diseases (caused by types of worms) Tapeworms: Pork or beef Pork tapeworm in brain Scolex of tapeworm that attaches to gut wall

19. Flukes: Schistosomiasis (liver flukes and blood flukes)

20. Nematodes: Various species affect the gastro-intestinal tract notably Ascaris Lumbricoides (Large Intestinal Roundworms)Ascaris Lumbricoides (Large Intestinal Roundworms)

21. Also cause Guinea worm

22. And Elephantiasis

23. Answer these questions What things may cause infections?Why does an infection take a while to develop?Why does an infection make you ill?Why do you get better from most infections?Why might you not be able to catch the same infection again?

24. Homework Find out about a disease causing organism and write about it. Your report must contain the following: A description of the disease causing organism (include a picture). (5 points) A description of the symptoms of the disease – include information on potential morbidity. (3 points) Methods of treatment and prevention. (3 points) Methods of transmission of the disease. (2 points) Discovery of the disease causing organism. (1 point) Regions of the globe and or sections of society most affected by it. (2 points) You must not copy and paste! You must include references! (English 3 points, refs 1 point) Total 20 points

25. Alternative In pairs develop a five minute presentation about one of the diseases named in this lesson: MRSA, Gonnorhoea, Salmonella, Botulism, TB, Syphilis, Lyme Disease, Leprosy, HIV, chicken pox, mumps, measles, common cold, rota virus, creuzfeld jacob, athletes foot, amoebic dysentry, giardia, sleeping sickness, toxoplasmosis, pork tapeworm, liver flukes, schistosomiasis, ascariasis, guinea worm and elephantiasis. Use guidance from homework slide to show what must be included in your presentation.