1. IT’S COMPLICATED: T1D Complications BIONIC MAN: My experience in the Artificial Pancreas Clinical Trials Tom Brobson JDRF

2. IT’S COMPLICATED: T1D Complications Session Overview 1.Why an artificial pancreas? 2.When it started. 3.Where it is now… 4.What the future holds…

3. IT’S COMPLICATED: T1D Complications An Artificial Pancreas

4. IT’S COMPLICATED: T1D Complications Why is an Artificial Pancreas Important? 36% of day too high + 5% of day too low ______________________________________________________________________________________________________________ 41% of the day spent “out of bounds”

5. IT’S COMPLICATED: T1D Complications 2007

6. IT’S COMPLICATED: T1D Complications  9:30 pm to 8:00 am – btwn 80 & 110  48% less insulin!  Shut off my basal!?!?  Lows: 6 v. 1  Highs: 1 v. 1  Time out of range: 1 hour v. 4 hours 2007: Me v. Artificial Pancreas

7. IT’S COMPLICATED: T1D Complications 2009

8. IT’S COMPLICATED: T1D Complications 2012

9. IT’S COMPLICATED: T1D Complications 2012

10. IT’S COMPLICATED: T1D Complications 2012  Five Guys Cheeseburger & some fries!  Hot Fudge Sundae  Running around all day  Watching TV  Hanging Out!

11. IT’S COMPLICATED: T1D Complications So what’s next?  More testing & development  More trials – think big  Next Generation Sensors  New Approaches to Insulin Delivery  Multi-hormone Your Support is Vital: Join Us!

12. IT’S COMPLICATED: T1D Complications Q & A Your Support is Vital: Join Us!