1. Cell Signaling Communication between cells near and far… 1994 Nobel Prize in Physiology/Medicine

2. How could cell signalling relate to cancer???

3. Press Release From the reading determine: –What is a G protein? –How does a G protein become activated? –What can G proteins do in a cell? –How does the Cholera toxin affect G-protein signaling? –What is the role of a discriminator? An amplifier?

4. Types of Signaling Paracrine Synaptic Hormonal –Plants –Animals

5. Overview of Cell Signalling Campbell’s 11A –Ligand –Reception –Transduction –Response

6. Types of Receptors Campbell’s 11B –G protein –Tyrosine Kinase –Ligand Gated Ion Channels

7. Signal Transduction Pathways Campbell’s 11C –Second messenger –Protein Kinase

8. Types of Cellular Response Campbell’s 11D; G protein animation http://www.physioviva.com/movies/gpcr/inde x.html –Types of Cellular Responses: Activation of a molecule. Turning on/off protein Gene activation Opening/closing of ioin channels.

9. Activity: G-protein signal transduction You will be part of a g-protein signal pathway. 1.Identify yourself: Reception, Transduction, Cellular Response 2.What is your role?

10. Experiment: Determining Environmental Conditions and Molecules used for signaling Case Study for Chapter 11

11. Human Growth Hormone Connection Normal Activity Altered Activity: Why would Roger Clemens take HgH? Problems associated with taking HgH

12. How is HgH different than testosterone? Testosterone is a steroid –How is the signaling pathway different?

13. Common Link: Destruction of Negative Feedback

14. Followup- -Bitter Taste Why do only some people taste bitter?