1. U.S. Interventional Cardiology Markets Changing Demographic Conditions and New Market Opportunities to Boost Growth “Greater incidence of cardiovascular and other chronic diseases due to an increase in the aging population and unhealthy habits such as smoking, poor diet, and lack of exercise are driving the demand for interventional cardiology products used in angioplasty, stenting, and vascular closure procedures.” Medical Devices Analyst Team Frost & Sullivan

2. A major factor affecting the U.S. cardiovascular products industry is demographics, particularly an aging population that increasingly requires products used in cardiovascular procedures such as angioplasty, stenting, coronary artery bypass grafting (CABG), etc. The population of Americans over the age of 65 is expected to grow by 50 percent in the next 30 years. Another important trend is the continued focus on healthcare cost containment by managed care entities and the hospital supply purchasing collectives. The pricing of high-tech devices has held up fairly well in this environment; however, as the industry has launched numerous new products with attractive cost/benefit profiles, pricing pressure continues to heat up. Industry Trends

3. Currently, the total cardiovascular market is expanding into new market opportunities such as drug-coated coronary stents, congestive heart failure devices, and robotic surgery. Other notable trends include industry wide consolidation, and increased emphasis on international markets such as Europe, Asia, Eastern Europe, and other emerging markets. Industry Trends (Cont’d)

4. Frost & Sullivan provides: Detailed insights into recent developments and trends Drivers, restraints, challenges, and strategic recommendations Analyst insights on ‘hot topics’ and emerging applications in the U.S. Interventional Cardiology Markets Market sizing and competitive analysis Market forecasts and opportunity analysis Detailed revenue breakdowns for both bone growth and spinal fusion stimulators in both external and implantable designs Detailed discussion of emerging applications for PEMF technology and stimulation synergies with orthobiologics Key Features

5. Coverage of United States market which generates the vast majority of revenues in the bone growth and spinal fusion stimulator market Proven methodology encompassing extensive primary and secondary data and research Focused information and strategies that cover business and technology issues Credible data and analysis highlighting industry dynamics Winning strategies to help you create precise business plans What We Offer

6. Current Market Participants Accurate third-party assessment of market for use in business planning Assess current and future drivers and restraints Determine and exploit new application opportunities Find detailed, market sizing numbers for your own planning needs New Entrants Analyze challenges associated with the industry Learn about winning strategies used by existing competitors Position yourself to capitalize on the market’s unmet needs Third-party market estimations for use in business plans Investment Community Analyze long-term strategies of companies selling stimulators Determine which participants will outperform the competition Assess attractiveness of investing in market Who Will Benefit?

7. What’s Included Guidant, JNJ/Cordis, Boston Scientific dominate the Interventional Cardiology market because of their broad product lines. The Interventional Cardiology market encompasses many types of products, but this report only profiles selected segments: Angioplasty Balloons Coronary Stents with a focus on Drug-Eluting Stents Peripheral Stents Intravascular Ultrasound (IVUS) Vascular Closure

8. Boston Scientific Guidant Johnson & Johnson (Cordis) Medtronic St. Jude Medical Edwards LifeSciences Key Market Participants

9. Call toll free 877 G O F ROST (877.463.7876) Fax toll free 888.690.3329 Email myfrost@frost.com Visit www.frost.com For More Information