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A Case Study Of A Man With Leukemia. A Chromosomal Translocation is Discovered.

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Presentation on theme: "A Case Study Of A Man With Leukemia. A Chromosomal Translocation is Discovered."— Presentation transcript:

1 A Case Study Of A Man With Leukemia

2 A Chromosomal Translocation is Discovered

3 PDGFR-beta null mutants are embryonically lethal

4 PDGFR alpha and beta have different downstream consequences Angiogenesis Lymphocytes Metabolism

5 The PDGF receptor can activate many Different Pathways

6 The ETV6-PDGFRB fusion causes constitutive dimerization

7 Chronic Myelomonocytic Leukemia (CMML) Is a Cancer of the Monocytes

8 Sources http://genesdev.cshlp.org/content/8/16/1888.full.pdf+html http://ac.els-cdn.com/0092867494903220/1-s2.0- 0092867494903220-main.pdf?_tid=a610a68e-95bd-11e2-a4ae- 00000aab0f01&acdnat=1364265434_56d0ab4e796e33281e0ce6e8 1475c3b2 http://ac.els-cdn.com/0092867494903220/1-s2.0- 0092867494903220-main.pdf?_tid=a610a68e-95bd-11e2-a4ae- 00000aab0f01&acdnat=1364265434_56d0ab4e796e33281e0ce6e8 1475c3b2 http://www.cancer.gov/cancertopics/pdq/treatment/mds- mpd/HealthProfessional/page2 http://www.cancer.gov/cancertopics/pdq/treatment/mds- mpd/HealthProfessional/page2 http://clincancerres.aacrjournals.org/content/16/12/3094.full http://www.sciencedirect.com/science/article/pii/S0025619611612 378# http://www.sciencedirect.com/science/article/pii/S0025619611612 378# http://www.cancer.org/cancer/leukemia- chronicmyelomonocyticcmml/detailedguide/leukemia-chronic- myelomonocytic-diagnosed http://www.cancer.org/cancer/leukemia- chronicmyelomonocyticcmml/detailedguide/leukemia-chronic- myelomonocytic-diagnosed http://www.plosone.org/article/info:doi/10.1371/journal.pone.000 3794 http://www.plosone.org/article/info:doi/10.1371/journal.pone.000 3794


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