1. N.meningitidis Ceftriaxone- children and adults Cefotaxime- neonates Ampicillin Chloramphenicol N. gonorrhea Ceftriaxone Cefotaxime Ciprofloxacin Spectinomycin

2. Pseudomonas aeruginosae Piperacillin+ gentamicin – other than UT Ceftazidime+ gentamicin- - do- Aztreonam,Imipenem Ciprofoxacin- preffered in UTI

3. H. influenzae, M. cattarrhalis Amoxicillin Cefaclor Cefuroxime axetil Cefprozil Cefixime Clarithromycin, azithromycin Imipenem

4. Staph. Aureus Mehicillin Cephazoline Vancomycin Clindamycin Macrolides Bacitracin- topical Imipenem

5. S. pyogenes, S. pneumoniae Penicillin v Cephalexin Clarithromycin, azithromycin Bacteroides fragilis Metronidazole Cefoxitin Clindamycin Imipenem

6. Clostridium difficile Metronidazole Vancomycin Imipenem Prophylaxis for surgery a) staph. Aureus; staph. Epidermidis cefazoline vancomycin (mrsa) b) bacteroides fragilis cefoxitin clindamycin

7. Diabetic foot infections with osteomyelitis p. aeruginosae, staph. Aureus, b. fragilis piperacillin/ tazobactam ticaracillin/ clavulanate ampicillin/ sulbactam imipenem/ cilastatin vancomycin aminoglycosides ciprofloxacin clindamycin- s.aureus & b.fragilis * combination therapy often includes clindamycin in addition to these antibiotics. Clindamycin is often used together with ciprofloxacin

8. Infected burns Mafenide acetate – p. aeruginosae Silver sulphadiazine- p. aeruginosae Bacitracin- staph. Aerus Aminoglycosides Osteomyelitis Ciprofloxacin Clindamycin (s.aureus, b.fragilis)

9. Brucella Doxycycline(mild cases) Doxycycline+ streptomycin or rifampin(severe cases) Ciprofloxacin Streptomycin & gentamicin Rifampin TMP-SMX Mycoplasma pneumoniae Doxycycline or ciprofloxacin- adults Macrolides- children

10. Legionella (Legionnaires' disease) Azithromycin- highly effective Quinolones- highly effective Severely ill pts azithromycin or ciprofloxacin with rifampin. Tetracycline(doxycycline, minocycline)- alternative TMP-SMX- alternative. * Erythromycin, the former choice has been replaced by more potent & less toxic antibiotics.Newer macrolides are preffered. Problem with erythromycin: excessive volume load, GI intolerance and ototoxicity.

11. Acne (propioni bacteria) Azithromycin Doxycycline Clindamycin(topical only)