1. The Chemistry of Perpetual Memory From Mechanisms of Memory by J. David Sweatt, Ph.D.

2. 32 P Incorporation into protein or adenine nucleotides Time (hrs) 32 P added Steady State Hypothetical graph of 32 P-PO 4 reaching steady state

3. C B A Half-life of AMPA receptors Mammen, Huganir, and O’Brien. (1997) J. Neurosci. 17:7351-7358.

4. The Rapid Rate of Protein Turnover Isoelectic Point310 Molecular Weight High (approx 200 kDa) Low (approx 5 kDa) Sweatt and Kandel, unpublished data

5. Rapid Basal Actin Turnover in Dendritic Spines Star, Kwiatkowski, and Murthy (2002) Nat. Neurosci. 5:239-246.

6. Gill-and-siphon Complex Gill/Siphon sensory Neuron MN SN Gill Withdrawal Muscle Tail Tail Sensory Neuron 5HT Gill and Siphon-withdrawal reflex circuitry in Aplysia SN

7. Swimming ContactWithdrawal Preparation for swimming Tritonia Escape Response Willows (1971) Sci. Am. 224:68-75

8. Ventral flexion Dorsal flexion A B Willows (1971) Sci. Am. 224:68-75 Tritonia Escape Response

9. Substrates PO 4 Substrates Ubiquitin-mediated proteolysis Facilitation of Neurotransmitter release PDE cAMP AMP cAMP Shorter Term Longer Term PKA Altered Gene Expression and Reg.Cat. Reg.Cat. Reg.Cat. Reg. Cat. Reg.Cat. Reg.Cat. Longer Term Schwartz and Kandel Model of Regulation of PKA in Aplysia

10. 1. “S” Channels 2. Kv channels 3. Release Machinery Action Potential Effectors of PKA and PKC in presynaptic facilitation

11. The Eskin/Byrne Model for the Expression of TBL-1 in Aplysia Liu et al. (1997) J. Neurosci. 17:755-764.