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Insulin’s Weighted Model 1984 transcripts’ weighted models overlap with insulin’s weighted model Ping Wang.

Published byMaximilian Osborne Modified over 8 years ago

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Presentation on theme: "Insulin’s Weighted Model 1984 transcripts’ weighted models overlap with insulin’s weighted model Ping Wang."— Presentation transcript:

1 Insulin’s Weighted Model 1984 transcripts’ weighted models overlap with insulin’s weighted model Ping Wang

2 Insulin linkage via scanone Ping Wang

3 Insulin’s Model Plots Ping Wang How many islet transcripts show this same genetic dependence at these loci?

4 Modules for 1984 transcripts with similar genetic architecture as insulin contains the insulin trait Ping Wang

5 SetPvalueQvalueCountSizeTerm MF5.04E-083.18E-051155332cytoplasm MF7.41E-083.18E-05773036cytoplasmic part MF6.20E-060.0017730863mitochondrion MF2.17E-050.004641478175intracellular part MF4.27E-050.0073191508478intracellular BP0.0005030.046341301068biosynthetic process MF0.0004910.0463411226796organelle CC0.0005410.046341548 oxidoreductase activity, acting on the CH-CH group of donors BP0.0006040.0470418511cellular lipid metabolic process Ping WangMapping by BIM

6 Ping Wang SetPvalueQvalueCountSizeTerm MF5.04E-083.18E-051155332cytoplasm MF7.41E-083.18E-05773036cytoplasmic part MF6.20E-060.0017730863mitochondrion MF2.17E-050.004641478175intracellular part MF4.27E-050.0073191508478intracellular BP0.0005030.046341301068biosynthetic process MF0.0004910.0463411226796organelle CC0.0005410.046341548 oxidoreductase activity, acting on the CH-CH group of donors BP0.0006040.0470418511cellular lipid metabolic process Mapping by BIM

7 SetPvalueQvalueCountSizeTerm MF1.74E-050.003307693extracellular matrix part CC1.61E-050.003307429 extracellular matrix structural constituent conferring tensile strength MF6.31E-050.007993437collagen MF0.0002250.0172868278proteinaceous extracellular matrix MF0.0002480.0172868282extracellular matrix CC0.0002730.017286459extracellular matrix structural constituent BP0.0008420.04571476phosphate transport Ping WangMapping by BIM

8 SetPvalueQvalueCountSizeTerm BP0.0011210.01651472769 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process MF0.0012970.016514116792intracellular organelle MF0.0013050.016514116796organelle MF0.0033640.0215284830cytoskeleton BP0.0082550.024184111pyrimidine ribonucleotide metabolic process BP0.0082550.024184111 pyrimidine ribonucleotide biosynthetic process BP0.0082550.024184111regulation of protein stability MF0.0085040.024184118175intracellular part BP0.0090030.024687112 transcription initiation from RNA polymerase II promoter Ping WangMapping by BIM

9 SetPvalueQvalueCountSizeTerm BP0.0077560.013822268sensory perception of sound BP0.009370.013822275sensory perception of mechanical stimulus MF0.0050810.013822261basement membrane Ping WangMapping by BIM

10 SetPvalueQvalueCountSizeTerm MF4.63E-073.96E-05563chromosome, pericentric region BP2.54E-050.0010887313cell cycle process BP0.0001470.004045179microtubule-based process BP0.0004250.004045225mitotic cell cycle BP0.0004510.004045228M phase BP0.000560.004045239cell division MF0.0003290.00404211condensed chromosome, pericentric region MF0.0005150.00404111428non-membrane-bound organelle MF0.0005150.00404111428intracellular non-membrane-bound organelle MF0.0006180.00404142243intracellular organelle part MF0.0006420.00404142251organelle part MF0.0007010.004045288chromosomal part Ping WangMapping by BIM

11 Ping WangMapping by BIM

12 SetPvalueQvalueCountSizeTerm MF0.0001680.0467286120anchored to membrane Ping WangMapping by BIM

13 SetPvalueQvalueCountSizeTerm MF7.41E-050.01147232037extracellular region part MF7.53E-050.01147262483extracellular region MF8.99E-050.01147221919extracellular space Ping WangMapping by BIM

14 SetPvalueQvalueCountSizeTerm BP0.0057190.144188496response to pheromone Ping WangMapping by BIM

15 Ping WangMapping by BIM qvaluePvalueCountSizeTerm 0.06190.00167213steroid hormone receptor signaling pathway

16 SetPvalueQvalueCountSizeTerm BP0.0001980.08300717279 enzyme linked receptor protein signaling pathway Ping WangMapping by BIM

17 SetPvalueQvalueCountSizeTerm BP0.0004120.060848214vesicle organization and biogenesis Ping WangMapping by BIM

18 SetPvalueQvalueCountSizeTerm BP0.0004120.060848214vesicle organization and biogenesis Ping WangMapping by BIM

19 Ping Wang 1 2 Mapping by BIM

20 Ping Wang 1 2 Mapping by BIM

21 Ping Wang 1 2 Mapping by BIM

22 Ping Wang 1 2 Mapping by BIM

23 Ping WangMapping by BIM

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